2013 Fiscal Year Final Research Report
Basic study of neuroregenerative therapy for diabetic polyneuropathy
| Project/Area Number |
23591260
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUNADA Yoshihide 川崎医科大学, 医学部, 教授 (00240713)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 糖尿病性多発神経炎 / 神経再生治療 / 血管内皮増殖因子 |
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| Research Abstract |
To elucidate the neuroregenerative effect of VEGF gene therapy, we examined sensory neuropathy in STZ diabetic mice. We found that both impaired maturation of myelinated fibers and atrophy of unmyelinated fibers simultaneously occur in the early stage of diabetes in these mice. In sciatic nerves, increased gene expression in VEGF signaling pathways, and reduction of PGE2 contents were observed. Retrograde transport of VEGF was not recognized in the mice.
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