2013 Fiscal Year Final Research Report
Targeting inflammation-immune response as a novel strategy for the treatment of brain infarction
| Project/Area Number |
23591262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳梗塞 / TLR / DAMPs / Peroxiredoxin / マクロファージ / インターロイキン23 / インターロイキン17 / γδT細胞 |
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| Research Abstract |
Immune responses following stroke continue to be an active area of investigation. Prior work has shown that lymphocytes lead to worsened outcome. However, the role of T lymphocyte subtypes has not been well studied. We have recently reported that the gamma-deltaT cells can produce IL-17 following stimulation by macrophage derived IL-23. These cytokines appear to contribute negatively to stroke evolution, as mice deficient in these cytokines are protected. In this study, peroxiredoxin (Prx), an endogenous antioxidant, was identified as a danger signal. Prx is shown to induce IL-23 and leads to worsened stroke outcome through toll-like receptors-2 and -4 pathway. These findings show that Prx is a novel damage-associated molecular patterns (DAMPs) and inhibiting Prx appears to be protective.
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[Journal Article] Plasma S100A12 is associated with functional outcome after ischemic stroke : Research for Biomarkers in Ischemic Stroke2014
Author(s)
Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Hata J, Gotoh S, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T; REBIOS Investigators
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Journal Title
J Neurol Sci
Volume: 340
Pages: 75-9
Peer Reviewed
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[Journal Article] High blood pressure after acute ischemic stroke is associated with poor clinical outcomes : Fukuoka Stroke Registry2014
Author(s)
Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators (Ooboshi H)
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Journal Title
Hypertension
Volume: 63
Pages: 54-60
Peer Reviewed
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[Journal Article] Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain2012
Author(s)
Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, Yoshimura A
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Journal Title
Nat Med
Volume: 18
Pages: 911-7
Peer Reviewed
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[Presentation] Basic fibroblast growth factor after ischemic stroke in diabetic patients - Research for Biomarkers in Ischemic Stroke (REBIOS) -2014
Author(s)
Nakamura K, Ago T, Arimura K, Makihara N, Nishimura A, Matsuo R, Kuroda J, Wakisaka Y, Isomura T, Awano H, Suzuki K, Okada Y, Kamouchi M, Kiyohara Y, Ooboshi H, Kitazono T
Organizer
International Stroke Conference 2014
Place of Presentation
San Diego, USA
Year and Date
2014-02-12
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[Presentation] The expression of pericyte PDGFRβis regulated by basic FGF after ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS) -2013
Author(s)
Nakamura K, Arimura K, Ago T, Makihara N, Isomura T, Watabe W, Awano H, Suzuki K, Kamouchi M, Kiyohara Y, Ooboshi H, Kitazono T
Organizer
Neuroscience Meeting 2013
Place of Presentation
San Diego, USA
Year and Date
2013-11-09
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[Presentation] Extracellular newly identified receptor for advanced glycation endproducts binding protein (EN-RAGE) predicts the outcome in patients with acute ischemic stroke : Research for Biomarkers in Ischemic Stroke2013
Author(s)
Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Gotoh S, Watanabe W, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T
Organizer
International Stroke Conference 2013
Place of Presentation
Honolulu, USA
Year and Date
2013-02-06
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