In vivo visualization of synuclein deposition in multiple system atrophy and its clinical applicability

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591266
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Tohoku University
• Principal Investigator: KIKUCHI Akio 東北大学, 大学病院, 助教 (80463785)
• Research Collaborator: TAKEDA Atsushi 独立行政法人国立病院機構, 仙台西多賀病院, 院長 (70261534) ; OKAMURA Nobuyuki 東北大学, 医学系研究科, 准教授 (40361076) ; FURUMOTO Shozo 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00375198) ; TASHIRO Manabu 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477) ; FUNAKI Yoshihito 東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (50261491)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 多系統萎縮症 / パーキンソン病 / PET / [11C]BF-227 / α-シヌクレイン

Outline of Final Research Achievements

The histopathological hallmark of multiple system atrophy (MSA) is the appearance of glial cytoplasmic inclusions, which are mainly composed of α-synuclein fibrils. We aimed to study whether [11C] 2-(2-[2-dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy) benzoxazole (BF-227) positron emission tomography (PET) can show time-dependent changes of α-synuclein deposits in brain lesions in four MSA with predominant cerebellar ataxia (MSA-C) patients using the Easy Z-Score Imaging System software. [11C]BF-227 PET showed time-dependent increases of tracer uptake in brain lesions such as the subcortical white matter and from frontal to parietal cortex in all four MSA-C patients. We suggest that [11C]BF-227 PET can be used as a surrogate marker of in vivo α-synuclein deposition in MSA-C.

Free Research Field

神経内科