2013 Fiscal Year Final Research Report
Novel methods to evaluate neuropathic pain by nerve excitability testing
Project/Area Number |
23591267
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
|
Research Institution | Chiba University |
Principal Investigator |
KUWABARA SATOSHI 千葉大学, 医学(系)研究科(研究院), 教授 (70282481)
|
Co-Investigator(Kenkyū-buntansha) |
MISAWA Sonoko 千葉大学, 大学院医学研究院, 助教 (30375753)
ITOH Sho-ichi 千葉大学, 大学院医学研究院, 講師 (60376374)
|
Project Period (FY) |
2011 – 2013
|
Keywords | 神経障害性疼痛 / 糖尿病性神経障害 / 軸索興奮性 / 臨床神経生理学 |
Research Abstract |
Pain-rerlated brain potentials, axonal excitability testing, and brain blood flow measurements were performed in patients with chronic neuropathic pain, and normal controls. Axonal persistent sodium currents were significantly increased in chronic pain patients, and the abnormally increased currents were suppressed by a Sodium channel blocker, mexiletine, associated with pain relief. In some patients with chronic pain, pain-related potentials were increased and blood flow of the limbic system was increased. These findings suggest peripheral generation of pain, and central sensitization, particularly in the linbic system.
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Author(s)
Nasu S, Misawa S, Nakaseko C, Shibuya K, Isose S, Sekiguchi Y, Mitsuma S, Ohmori S, Iwai Y, Beppu M, Shimizu N, Ohwada C, Takeda Y, Fujimaki Y, Kuwabara S
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Journal Title
Clin Neurophysiol
Volume: 125(2)
Pages: 381-7
DOI
Peer Reviewed
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[Journal Article] Differences in excitability between median and superficial radial sensory axons2012
Author(s)
Fujimaki Y, Kanai K, Misawa S, Shibuya K, Isose S, Nasu S, Sekiguchi Y, Ohmori S, Noto Y, Kugio Y, Shimizu T, Matsubara S, Lin CS, Kuwabara S
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Journal Title
Clin Neurophysiol
Volume: 123
Pages: 1440-5
DOI
Peer Reviewed
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