Dynamics of brain functional connectivity associated with alternation of consciousness

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591273
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: MATSUMOTO Riki 京都大学, 医学(系)研究科(研究院), 准教授 (00378754)
• Co-Investigator(Kenkyū-buntansha): 池田 昭夫 京都大学, 医学研究科, 教授 (90212761) ; 國枝 武治 京都大学, 医学研究科, 講師 (60609931) ; 澤本 伸克 京都大学, 医学研究科, 講師 (90397547) ; 松橋 眞生 京都大学, 脳機能総合センター (40456885)
• Project Period (FY): 2011 – 2013
• Keywords: 機能的結合 / 皮質間ネットワーク / 意識変容 / てんかん / 睡眠 / 皮質皮質間誘発電位 / 脳波機能的ＭＲＩ同時計測 / デフォルト・モード・ネットワーク

Research Abstract

Despite its significance in clinical neuroscience, the dynamic alternation of brain networks associated with alternation of consciousness still remains elusive. By means of invasive (cortico-cortical evoked potential: CCEP) and non-invasive (simultaneous recording of EEG and fMRI: EEGfMRI) methods that probe the brain connectivity or network, we investigated sleep, namely, physiological alternation of consciousness, and epileptic encephalopathy, a model of pathological chronic alternation of consciousness, respectively. The CCEP study revealed that cortico-cortical connectivity/excitability dynamically modulated as the sleep stage changed and its degree differed among lobes. EEGfMRI in patients with hypothalamic hamartoma (a model disease of epileptic encephalopathy) revealed that epileptic spikes decreased neural activities in the default mode network (DMN). Chronic exposure to spikes resulted in impairment of DMN and likely led to epileptic encephalopathy.

Research Products

• [Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation (2014)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, IkedaA, Fukuyama H, Miyamoto S
  • Journal Title: Hum Brain Mapp Volume: (in press)(E-pub)
  • DOI: 10.1002/hbm.22479
• [Journal Article] Temporal Lobe Epilepsy with Amygdala Enlargement : A Morphologic and Functional Study (2014)
  • Author(s): Takaya S, Ikeda A, Mitsueda-Ono T, MatsumotoR, Inouchi M, Namiki C, Oishi N, Mikuni N, Ishizu K, Takahashi R, Fukuyama H
  • Journal Title: J Neuroimaging Volume: 24 Pages: 54-62
  • DOI: 10.1111/j.1552-6569.2011.00694.x
• [Journal Article] 側頭葉てんかんの認知機能と扁桃体 (2014)
  • Author(s): 武山博文,松本理器,三枝隆博,池田昭夫
  • Journal Title: Clinical Neuroscience Volume: 32(6)(総説) Pages: 680-2
• [Journal Article] Evaluation of Focus Laterality in Temporal Lobe Epilepsy : A Quantitative Study Comparing Double Inversion-Recovery MR Imaging at 3T with FDG-PET (2013)
  • Author(s): Morimoto E, Okada T, Kanagaki M, Yamamoto A, Fushimi Y, Matsumoto R, Takaya S, Ikeda A, Kunieda T, Kikuchi T, Paul D, Miyamoto S, Takahashi R, Togashi K
  • Journal Title: Epilepsia Volume: 54 Pages: 5174-83
  • DOI: 10.1111/epi.12396
• [Journal Article] Role of posterior parietal cortex in reaching movements in humans : Clinical implication for 'optic ataxia' (2013)
  • Author(s): Inouchi M, MatsumotoR, Taki J, Kikuchi T, Mitsueda-Ono T, Mikuni N, Wheaton L, Hallett M, Fukuyama H, Shibasaki H, Takahashi R, IkedaA
  • Journal Title: Clin Neurophy siol Volume: 124 Pages: 2230-2241
  • DOI: 10.1016/j.clinph.2013.05.011
• [Journal Article] Dysembryoplastic neuroepithelial tumor with rapid recurrence of pilocytic astrocytoma component (2013)
  • Author(s): Takeuchi Y, Arakawa Y, Mikami Y, Matsumoto R, Miyamoto S
  • Journal Title: Brain Tumor Pathol Volume: 31 Pages: 144-8
  • DOI: 10.1007/s10014-013-0155-z
• [Journal Article] Pre-SMA actively engages in conflict processing in human : A combined study of epicortical ERPs and direct cortical stimulation (2013)
  • Author(s): Usami K, Matsumoto R, Kunieda T, Shimotake A, Matsuhashi M, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Neuropsychologia Volume: 51 Pages: 1011-1017
  • DOI: 10.1016/j.neuropsychologia.2013.02.002
• [Journal Article] Bereitschaftspotential augmentation by neuro-feedback training in Parkinson's disease (2013)
  • Author(s): Fumuro T, Matsuhashi M, Mitsueda T, Inouchi M, Hitomi T, Nakagawa T, Matsumoto R, Kawamata J, Inoue H, Mima T, Takahashi R, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 124 Pages: 1398-405
  • DOI: 10.1016/j.clinph.2013.01.026
• [Journal Article] Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator of seizure focus laterality in temporal lobe epilepsy : comparison of double inversion-recovery, FLAIR and T2W MR imaging (2013)
  • Author(s): Morimoto E, Kanagaki M, Okada T, Yamamoto A, Mori N, Matsumoto R, Ikeda A, Mikuni N, Kunieda T, Paul D, Miyamoto S, Takahashi R, Togashi K
  • Journal Title: Eur Radiol Volume: 23 Pages: 3-11
  • DOI: 10.1007/s00330-012-2565-4
• [Journal Article] Internal structural changes in the hippocampus observed on 3-Tesla MRI in patients with mesial temporal lobe epilepsy (2013)
  • Author(s): Mitsueda-Ono T, Ikeda A, Sawamoto N, Aso T, Hanakawa T, Kinoshita M, Matsumoto R, Mikuni N, Amano S, Fukuyama H, Takahashi R
  • Journal Title: Int ernal Medicine Volume: 52(Epub 2013 Apr 15) Pages: 877-885
• [Journal Article] Cortical negative motor network in comparison with sensorimotor network : A cortico-cortical evoked potential study (2013)
  • Author(s): Enatsu R, Matsumoto R, Piao Z, O'Connor T, Horning K, Burgess RC, Bulacio J, Bingaman W, Nair DR
  • Journal Title: Cortex Volume: 49 Pages: 2080-2096
  • DOI: 10.1016/j.cortex.2012.08.026
• [Journal Article] Faciobrachial dystonic seizureで初発したくすぶり型の抗leucine-rich glioma-inactivated 1 (LGI1)抗体陽性辺縁系脳炎の1例 (2013)
  • Author(s): 中奥由里子,眞木崇州,金澤恭子,松本理器,福山秀直,高橋良輔,池田昭夫
  • Journal Title: 臨床神経学 Volume: 53 Pages: 706-711
  • URL: http://www.neurology-jp.org/Journal/index_j.html
• [Journal Article] てんかんと脳内ネットワーク機構 (2013)
  • Author(s): 松本理器,國枝武治,池田昭夫
  • Journal Title: 医薬ジャーナル Volume: 49(総説) Pages: 1312-1320
  • URL: https://www.iyaku-j.com/iyakuj/system/M2-1/summary_viewer.php?trgid=26660
• [Journal Article] Parieto-frontal network in humans studied by cortico-cortical evoked potential (2012)
  • Author(s): Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S, Fukuyama H, Takahashi R , Najm I, Shibasaki H, Lüders HO
  • Journal Title: Hum Brain Mapp Volume: 33 Pages: 2856-2872
  • DOI: 10.1002/hbm.21407
• [Journal Article] Asymmetric bilateral effect of the supplementary motor area proper in the human motor system (2012)
  • Author(s): Kikuchi T, Matsumoto R, Mikuni N, Yokoyama Y, Matsumoto A, Ikeda A, Fukuyama H, Miyamoto S, Hashimoto N
  • Journal Title: Clin Neurophysiol Volume: 123 Pages: 324-334
  • DOI: 10.1016/j.clinph.2011.06.011
• [Journal Article] 高次脳機能イメージングの脳科学への展開:皮質-皮質間誘発電位を用いたヒト大脳皮質間結合の探索 (2012)
  • Author(s): 松本理器,國枝武治,池田昭夫
  • Journal Title: BRAIN and NERVE Volume: 64(総説) Pages: 979-991
  • URL: http://ej.islib.jp/ejournal/1416101284.html
• [Journal Article] 臨床神経学と臨床神経科学の関連 (2012)
  • Author(s): 松本理器,國枝武治,高橋良輔,池田昭夫
  • Journal Title: 臨床神経学 Volume: 52(総説) Pages: 1084-1086
  • URL: http://www.neurology-jp.org/Journal/index_j.html
• [Journal Article] 陰性ミオクローヌス:発生機序と解析 (2012)
  • Author(s): 小林勝哉,松本理器
  • Journal Title: Clinical Neuroscience Volume: 30(総説) Pages: 807-812
• [Journal Article] Left anterior temporal cortex actively engages in speech perception : A direct cortical stimulation study (2011)
  • Author(s): Matsumoto R, Imamura H, Inouchi M, Nakagawa T, Yokoyama Y, Matsuhashi M, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Neuropsychologia Volume: 49 Pages: 1350-1354
  • DOI: 10.1016/j.neuropsychologia.2011.01.023
• [Journal Article] Current challenges in the practice of epilepsy surgery (2011)
  • Author(s): Wrench JM, MatsumotoR, Inoue Y, Wilson SJ
  • Journal Title: Epilepsy Behav Volume: 22(selected as promising young investigator in clinical epilepsy research ,総説) Pages: 23-31
  • DOI: 10.1016/j.yebeh.2011.02.011
• [Journal Article] Ictal wideband ECoG : Direct comparison between ictal slow shifts and high frequency oscillations (2011)
  • Author(s): Imamura H, Matsumoto R, Inouchi M, Matsuhashi M, Mikuni N, Takahashi R, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 122 Pages: 1500-1504
  • DOI: 10.1016/j.clinph.2010.12.060
• [Journal Article] Decreased cortical excitability in Unverricht-Lundborg disease in the long-term follow-up : A consecutive SEP study (2011)
  • Author(s): Kobayashi K, Matsumoto R, Kondo T, Kawamata J, Hitomi T, Inouchi M, Matsuhashi M, Takahashi R, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 122 Pages: 1617-1621
  • DOI: 10.1016/j.clinph.2011.01.039
• [Journal Article] Amygdalar enlargement in patients with temporal lobe epilepsy (2011)
  • Author(s): Mitsueda-Ono T, Ikeda A, Inouchi M, Takaya S, Matsumoto R, Hanakawa T, Sawamoto N, Mikuni N, Fukuyama H, Takahashi R
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 82 Pages: 652-657
  • DOI: 10.1136/jnnp.2010.206342
• [Journal Article] Importance of precentral motor regions in human kinesthesia : A single case study (2011)
  • Author(s): Naito E, Matsumoto R, Hagura N, Oouchida Y, Tomimoto H, Hanakawa T
  • Journal Title: Neurocase Volume: 17 Pages: 133-147
  • DOI: 10.1080/13554794.2010.498428
• [Journal Article] Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy (2011)
  • Author(s): Hitomi T, Ikeda A, Kondo T, Imamura H, Inouchi M, MatsumotoR, Terada K, Kanda M, Matsuhashi M, Nagamine T, Shibasaki H and Takahashi R
  • Journal Title: M ov Disord Volume: 26 Pages: 1509-1514
  • DOI: 10.1002/mds.23653
• [Journal Article] てんかんに対する電気生理学的アプローチの新知見–検査と治療 (2011)
  • Author(s): 27.金澤恭子,松本理器,木下真幸子,池田昭夫
  • Journal Title: BRAIN and NERVE Volume: 63(総説) Pages: 355-364
  • URL: http://ej.islib.jp/ejournal/1416100879.html
• [Journal Article] 脳のゆらぎ・同期・オシレーションC.ヒトでの計測6.皮質脳波
  • Author(s): 小林勝哉,松本理器
  • Journal Title: Clinical Neuroscience Volume: (in press,総説)
• [Presentation] In vivo investigation of functional brain networks by CCEPs. In Syposium : Single pulse electrical stimulation to probe human brain connectivity and epileptogenicity (2014)
  • Author(s): Matsumoto R
  • Organizer: International Congress of Clinical Neurophysiology (ICCN2014)
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-03-23
  • Invited
• [Presentation] Intraoperative language network monitoring by means of cortico-cortical evoked potentials (2014)
  • Author(s): Yukihiro Yamao, Riki Matsumoto, Takeharu Kunieda, Yoshiki Arakawa, Sumiya Shibata, Rika Inano, Takayuki Kikuchi, Nobukatsu Sawamoto, Nobuhiro Mikuni, Akio Ikeda, Hidenao Fukuyama, Susumu Miyamoto
  • Organizer: International Congre ss of Clinical Neurophysiology (ICCN2014)
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-03-21
• [Presentation] Correlation between scalp-recorded and subdural slow cortical potentials : direct comparison during neuro-feedback training (2014)
  • Author(s): Tomoyuki Fumuro, Riki Matsumoto, Masao Matsuhashi, Akihiro Shimotake, Kiyohide Usami, Takeharu Kunieda, Ryosuke Takahashi, Akio Ikeda
  • Organizer: International Congress of Clinical Neurophysiology (ICCN2014)
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-03-21
• [Presentation] てんかん病態下の脳内ネットワークの探索 (2014)
  • Author(s): 松本理器,國枝武治,池田昭夫
  • Organizer: 第37回日本脳神経CI学会
  • Place of Presentation: 大宮
  • Year and Date: 2014-02-28
  • Invited
• [Presentation] てんかんと脳内ネットワーク (2013)
  • Author(s): 松本理器,國枝武治,池田昭夫
  • Organizer: 第18回日本神経精神医学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-12-14
  • Invited
• [Presentation] Epileptic network associated with hypothalamic hamartoma : an EEG-fMRI study (2013)
  • Author(s): Kiyohide Usami, Riki Matsumoto, Nobukatsu Sawamoto, Hiroatsu Murakami, Morito Inouchi, Tomoyuki Fumuro, Akihiro Shimotake, Takeo Kato, Tatsuya Mima, Hiroshi Masuda, Hidenao Fukuyama, Shigeki Kameyama, Akio Ikeda
  • Organizer: Annual meeting of American Epilepsy Society 2013
  • Place of Presentation: Washington D.C., USA
  • Year and Date: 2013-12-08
• [Presentation] Basal temporal language area revisited in Japanese-its anatomy, function and connectivity (2013)
  • Author(s): Riki Matsumoto, Takeharu Kunieda, Akihiro Shimotake, Hisaji Imamura, Katsuya Kobayashi, Kiyohide Usami, Takayuki Kikuchi, Hidenao Fukuyama, Ryosuke Takahashi, Nobuhiro Mikuni, Susumu Miyamoto, Akio Ikeda
  • Organizer: Annual meeting of American Epilepsy Society 2013
  • Place of Presentation: Washington D.C., USA
  • Year and Date: 2013-12-08
• [Presentation] ヒトの睡眠は大脳皮質の興奮性・機能的結合性を変容させる:てんかん性放電・皮質単発電気刺激からの知見(シンポジウム11てんかんと睡眠—その密接な関連性— (2013)
  • Author(s): 松本理器,宇佐美清英,國枝武治,池田昭夫
  • Organizer: 第43回日本臨床神経生理学会
  • Place of Presentation: 高知
  • Year and Date: 2013-11-08
  • Invited
• [Presentation] 機能的線維追跡法を用いた脳機能結合地図の臨床応用(シンポジウム5頭蓋内電極による脳機能検査の新展開) (2013)
  • Author(s): 松本理器,國枝武治,池田昭夫
  • Organizer: 第43回日本臨床神経生理学会
  • Place of Presentation: 高知
  • Year and Date: 2013-11-07
  • Invited
• [Presentation] 正常・てんかん病態下の脳機能結合地図 (2013)
  • Author(s): 松本理器
  • Organizer: 第25回臨床神経生理研究会(九州)
  • Place of Presentation: 福岡
  • Year and Date: 2013-08-17
  • Invited
• [Presentation] Dynamic modulation of neural oscillation under physiological and epileptic conditions (2013)
  • Author(s): Matsumoto R
  • Organizer: Neural Oscillation Conference 2013
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2013-07-18
  • Invited
• [Presentation] Language comprehension network : imaging cortico-cortical connectivity from the posterior middle temporal gyrus with cortical stimulation (2013)
  • Author(s): 松本理器,國枝武治,下竹昭寛,小林勝哉,宇佐美清英,三國信啓,福山秀直,高橋良輔,池田昭夫
  • Organizer: 第36回日本神経科学会
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] Basal temporal language area : Evidence from direct cortical stimulation and local field potential recording (2012)
  • Author(s): Matsumoto R
  • Organizer: World Federation of Neurology Research Group on Aphasia and Cognitive Disorders
  • Place of Presentation: Hyderabad, India
  • Year and Date: 2012-12-10
  • Invited
• [Presentation] HFO correlates of cortico-cortical evoked potentials reveal altered excitability in the human epileptic focus (2012)
  • Author(s): Katsuya Kobayashi, Riki Matsumoto, Masao Matsuhashi, Kiyohide Usami, Akihiro Shimotake, Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama, Ryosuke Takahashi, Akio Ikeda
  • Organizer: Annual meeting of American Epilepsy Society 2012
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-12-03
• [Presentation] Sleep stage changes connectivity in human cortices : A cortico-cortical evoked potential study (2012)
  • Author(s): Kiyohide Usami, Riki Matsumoto, Takefumi Hitomi, Katsuya Kobayashi, Akihiro Shimotake, Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama, Ryosuke Takahashi, Akio Ikeda
  • Organizer: Society for Neuroscience 2012
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-17
• [Presentation] Hypothalamic hamartoma and its epileptic network : an EEG-fMRI study (2012)
  • Author(s): Kiyohide Usami, Riki Matsumoto, Nobukatsu Sawamoto, Hiroatsu Murakami, Morito Inouchi, Tomoyuki Fumuro, Akihiro Shimotake, Minoru Shibata, Takeo Kato, Hiroshi Masuda, Tatsuya Mima, Hidenao Fukuyama, Ryosuke Takahashi, Shigeki Kameyama, Akio Ikeda
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-11
• [Presentation] Sleep Changes the Degree of Connectivity in Human Cortices (2012)
  • Author(s): Kiyohide Usami, Riki Matsumoto, Takefumi Hitomi, Katsuya Kobayashi, Akihiro Shimotake, Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama, Ryosuke Takahashi, AkioIkeda
  • Organizer: 第35回日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-21
• [Presentation] Invasive exploration of human parieto-frontal network for higher-order motor control (2012)
  • Author(s): Matsumoto R
  • Organizer: Korea - Japan Joint Symposium : Motor Network - Planning and Inhibition (JSPS)
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2012-02-23
  • Invited
• [Presentation] Impaired integrity of the tract between the focus and the remote functional deficit zone in mesial temporal lobe epilepsy : A combined study of FDG-PET and diffusion tractography (2011)
  • Author(s): Hisaji Imamura, Riki Matsumoto, Shigetoshi Takaya, Morito Inouchi, Hidenao Fukuyama, Ryosuke Takahashi, Akio Ikeda
  • Organizer: Annual meeting of American Epilepsy Society 2011
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2011-12-03
• [Presentation] Comparison between fMRI and direct cortical stimulation for Clinical retinotopic mapping (2011)
  • Author(s): Akihiro Shimotake, Riki Matsumoto, Masanori Kanazu, Hiroki Yamamoto, Masao Matsuhashi, Nobukatsu Sawamoto, Yukihiro Yamao, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama,Ryosuke Takahashi, Akio Ikeda
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] 高次運動機能に関わる前頭・頭頂葉ネットワーク−皮質-皮質間誘発電位.シンポジウム:マッピングからネットワークの解析へ (2011)
  • Author(s): 松本理器,三國信啓,池田昭夫
  • Organizer: 第13回日本ヒト脳機能マッピング学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-02
  • Invited
• [Book] 頭蓋内脳波記録, てんかん専門医ガイドブック (2014)
  • Author(s): 松本理器(日本てんかん学会編,編集書籍)
  • Total Pages: 105-109
  • Publisher: 診断と治療社, 東京
• [Book] てんかん脳波とその評価.脳神経外科医のための脳機能と局在診断
  • Author(s): 松本理器(橋本信夫監修, 編集書籍)
  • Publisher: (in press)
• [Remarks]
  • URL: http://epilepsy.med.kyoto-u.ac.jp