Neuronal network connectivity breakdown in basal ganglia and cerebellar disorders

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591274
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: SAWAMOTO Nobukatsu 京都大学, 医学(系)研究科(研究院), 講師 (90397547)
• Project Period (FY): 2011 – 2013
• Keywords: パーキンソン病 / 脊髄小脳変性症 / 神経機能画像 / 解剖学的結合 / トラクトグラフィー / 機能的結合 / 安静時機能的MRI

Research Abstract

In basal ganglia and cerebellar disorders, it is critical to investigate 'network dysfunction' in order to understand pathophysiological mechanisms from neuronal cell degeneration to clinical symptoms. Since the subcortical nuclei have no direct motor output, the network dysfunction should results in disordered outputs from the motor cortex reflecting the clinical symptoms. We employed tractography and resting state functional magnetic imaging techniques to investigate intrinsic neuronal network connectivity among the subcortical nuclei. We found that dopamine depletion in Parkinson disease lead to network connectivity breakdown between the striatum and anterior thalamus. The present findings suggest that functional connectivity breakdown among those subcortical structures are related to clinical symptoms in Parkinson disease.

Research Products

• [Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation (2014)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Hum Brain Mapp Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Global association between cortical thinning and white matter integrity reduction in schizophrenia (2014)
  • Author(s): Sasamoto A, Miyata J, Kubota M, Hirao K, Kawada R, Fujimoto S, Tanaka Y, Hazama M, Sugihara G, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: Schizophr Bull Volume: 40(2) Pages: 420-7
  • Peer Reviewed
• [Journal Article] Impact of gray matter reductions on theory of mind abilities in patients with schizophrenia (2013)
  • Author(s): Koelkebeck K, Hirao K, Miyata J, Kawada R, Saze T, Dannlowski U, Ubukata S, Ohrmann P, Bauer J, Pedersen A, Fukuyama H, Sawamoto N, Takahashi H, Murai T
  • Journal Title: Soc Neurosci Volume: 8(6) Pages: 631-9
  • Peer Reviewed
• [Journal Article] Neuroimaging in epilepsy(Review. Japanese) (2013)
  • Author(s): Yamao Y, Kunieda T, Kikuchi T, Matsuhashi M, Sawamoto N, Matsumoto R, Okada T, Miyamoto S, Ikeda A
  • Journal Title: Brain Nerve Volume: 65(5) Pages: 573-81
• [Journal Article] Overlapping connections within the motor cortico-basal ganglia circuit : fMRI-tractography analysis (2013)
  • Author(s): Oguri T, Sawamoto N, Tabu H, Urayama S, Matsuhashi M, Matsukawa N, Ojika K, Fukuyama H
  • Journal Title: Neuroimage Volume: 78 Pages: 353-62
  • Peer Reviewed
• [Journal Article] Internal structural changes in the hippocampus observed on 3-tesla MRI in patients with mesial temporal lobe epilepsy (2013)
  • Author(s): Mitsueda-Ono T, Ikeda A, Sawamoto N, Aso T, Hanakawa T, Kinoshita M, Matsumoto R, Mikuni N, Amano S, Fukuyama H, Takahashi R
  • Journal Title: Intern Med Volume: 52(8) Pages: 877-85
  • Peer Reviewed
• [Journal Article] Regional gray matter reduction correlates with subjective quality of life in schizophrenia (2013)
  • Author(s): Ubukata S, Miyata J, Yoshizumi M, Uwatoko T, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Sasamoto A, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: J Psychiatr Res Volume: 47(4) Pages: 548-54
  • Peer Reviewed
• [Journal Article] Thalamocortical disconnection in the orbitofrontal region associated with cortical thinning in schizophrenia (2013)
  • Author(s): Kubota M, Miyata J, Sasamoto A, Sugihara G, Yoshida H, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: JAMA Psychiatry Volume: 70(1) Pages: 12-21
  • Peer Reviewed
• [Journal Article] Alexithymia and reduced white matter integrity in schizophrenia : a diffusion tensor imaging study on impaired emotional self-awareness (2012)
  • Author(s): Kubota M, Miyata J, Sasamoto A, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: Schizophr Res Volume: 141(2-3) Pages: 137-43
  • Peer Reviewed
• [Journal Article] Pathological steps of cancer-related lymphedema : histological changes in the collecting lymphatic vessels after lymphadenectomy (2012)
  • Author(s): Mihara M, Hara H, Hayashi Y, Narushima M, Yamamoto T, Todokoro T, Iida T, Sawamoto N, Araki J, Kikuchi K, Murai N, Okitsu T, Kisu I, Koshima I
  • Journal Title: PLoS One Volume: 70(7) Pages: e41126
  • Peer Reviewed
• [Journal Article] Functional magnetic resonance imaging analysis of food-related brain activity in patients with lipodystrophy undergoing leptin replacement therapy (2012)
  • Author(s): Aotani D, Ebihara K, Sawamoto N, Kusakabe T, Aizawa-Abe M, Kataoka S, Sakai T, Iogawa H, Ebihara C, Fujikura J, Hosoda K, Fukuyama H, Nakao K
  • Journal Title: J Clin Endocrinol Metab Volume: 97(10) Pages: 3663-71
  • Peer Reviewed
• [Journal Article] Differential roles for parietal and occipital cortices in visual working memory (2012)
  • Author(s): Matsuyoshi D, Ikeda T, Sawamoto N, Kakigi R, Fukuyama H, Osaka N
  • Journal Title: PLoS One Volume: 7(6) Pages: e38623
  • Peer Reviewed
• [Journal Article] Pathophysiology of unilateral asterixis due to thalamic lesion (2012)
  • Author(s): Inoue M, Kojima Y, Mima T, Sawamoto N, Matsuhashi M, Fumuro T, Kinboshi M, Koganemaru S, Kanda M, Shibasaki H
  • Journal Title: Clin Neurophysiol Volume: 123(9) Pages: 1858-64
  • Peer Reviewed
• [Journal Article] Diffuse tract damage in the hemispheric deep white matter may correlate with global cognitive impairment and callosal atrophy in patients with extensive leukoaraiosis (2012)
  • Author(s): Otsuka Y, Yamauchi H, Sawamoto N, Iseki K, Tomimoto H, Fukuyama H
  • Journal Title: AJNR Am J Neuroradiol Volume: 33(4) Pages: 726-32
  • Peer Reviewed
• [Journal Article] Abnormal asymmetry of white matter integrity in schizophrenia revealed by voxelwise diffusion tensor imaging (2012)
  • Author(s): Miyata J, Sasamoto A, Koelkebeck K, Hirao K, Ueda K, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Fukuyama H, Sawamoto N, Takahashi H, Murai T
  • Journal Title: Hum Brain Mapp Volume: 33(7) Pages: 1741-9
  • Peer Reviewed
• [Journal Article] Transcultural differences in brain activation patterns during theory of mind (ToM) task performance in Japanese and Caucasian participants (2011)
  • Author(s): Koelkebeck K, Hirao K, Kawada R, Miyata J, Saze T, Ubukata S, Itakura S, Kanakogi Y, Ohrmann P, Bauer J, Pedersen A, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: Soc Neurosci Volume: 6(5-6) Pages: 615-26
  • Peer Reviewed
• [Journal Article] Social impairment in schizophrenia revealed by Autism-Spectrum Quotient correlated with gray matter reduction (2011)
  • Author(s): Sasamoto A, Miyata J, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: Soc Neurosci Volume: 6(5-6) Pages: 548-58
  • Peer Reviewed
• [Presentation] Striatal dopamine depletion lead to altered functional connectivity with the thalamus in Parkinson disease : a PET and fMRI study (2014)
  • Author(s): Inano R, Sawamoto N, Kunieda T, Kikuchi T, Tabu H, Okada T, Togashi K, Tahakahashi R, Fukuyama H, Miyamoto S
  • Organizer: 30th International Congress of Clinical Neurophysiology (ICCN) of the IFCN
  • Place of Presentation: Berlin, Germany
  • Year and Date: 20140319-23
• [Presentation] Intraoperative language network monitoring by means of cortico-cortical evoked potentials (2014)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Shibata S, Inano R, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
  • Organizer: 30th International Congress of Clinical Neurophysiology (ICCN) of the IFCN
  • Place of Presentation: Berlin, Germany
  • Year and Date: 20140319-23
• [Presentation] Altered awareness of action in Parkinson's disease (2014)
  • Author(s): Saito Na, Takahata K, Yamakado H, Sawamoto N, DOte S, Park P, Takahashi H, Murai T
  • Organizer: 30th International Congress of Clinical Neurophysiology (ICCN) of the IFCN
  • Place of Presentation: Berlin, Germany
  • Year and Date: 20140319-23
• [Presentation] パーキンソン病患者の特徴的な性格傾向の神経基盤 (2013)
  • Author(s): 澤本伸克、石井徹、椨勇人、小栗卓也、岡田知久、富樫かおり、高橋良輔、福山秀直
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 20130529-0601
• [Presentation] Intraoperative monitoring of perisylvian languate network by means of cortico-cortical evoked potentials (2012)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Takahashi R, Ikeda A, Fukuyama H, Miyamoto S
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20121013-17
• [Presentation] Striatal circuits may underlie novelty-seeking behavior (2012)
  • Author(s): Ishi T, Sawamoto N, Tabu H, Fukuyama H
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20121013-17
• [Presentation] Motor function after surgery : correlation between outcome and motor network connectivity (2012)
  • Author(s): Yamao Y, Sawamoto N, Kunieda T, Shibata S, Kikuchi T, Matsumoto R, Ikeda A, Fukuyama H, Miyamoto S
  • Organizer: 18th annual meeting of the organization on Human Brain Mapping
  • Place of Presentation: Beijing, China
  • Year and Date: 20120610-14
• [Presentation] A striatal network and dopaminergic regulation affect how we get along with others (2012)
  • Author(s): Ishi T, Sawamoto N, Tabu H, Okada T, Togashi K, Fukuyama H
  • Organizer: 18th annual meeting of the organization on Human Brain Mapping
  • Place of Presentation: Beijing, China
  • Year and Date: 20120610-14
• [Presentation] 基底核と大脳皮質をつなぐ機能的・解剖学的ネットワークのMRIを用いた検討 (2011)
  • Author(s): 澤本伸克, 小栗卓也, 椨勇人, 福山秀直
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] 統合失調症における眼窩前頭領域の視床皮質経路結合性低下および皮質の菲薄化について (2011)
  • Author(s): 久保田学, 宮田淳, 笹本彰彦, 吉田英史, 川田良作, 藤本心祐, 田中祐輔, 澤本伸克, 福山秀直, 高橋英彦, 村井俊哉
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] ヒトの視覚野内と視覚野間における最適空間周波数の違い:fMRI研究 (2011)
  • Author(s): 山本哲也, 山本洋紀, 三浦健一郎, 澤本伸克, 福山秀直, 河野憲二
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] 後頭葉てんかんにおける機能的MRIおよび皮質電気刺激を用いた統合的レチノトピーマッピング (2011)
  • Author(s): 下竹昭寛, 松本理器, 金津将庸, 山本洋紀, 松橋眞生, 澤本伸克, 山尾幸広, 三國信啓, 宮本享, 福山秀直, 高橋良輔, 池田昭夫
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Tract-based spatial statisticsを用いた統合失調症白質の非対称性異常の検討 (2011)
  • Author(s): 宮田淳, 笹本彰彦, ケルケベックカーチャ, 平尾和之, 上田敬太, 川田良作, 藤本心祐, 田中祐輔, 久保田学, 澤本伸克, 福山秀直, 高橋英彦, 村井俊哉
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] パーキンソン病における随意運動時の補足運動野活動低下についての検討 (2011)
  • Author(s): 椨勇人, 澤本伸克, 小栗卓也, 高橋良輔, 福山秀直
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] 記憶の検索中のトップ・ダウン信号に関わる前頭前野の活動 (2011)
  • Author(s): 後藤和宏, 金津将庸, 山本洋紀, 澤本伸克, 福山秀直, 船橋新太郎
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] Functional and anatomical architecture linking the basal ganglia and cortex : an MRI study (2011)
  • Author(s): Sawamoto N, Oguri T, Tabu H, Fukuyama H
  • Organizer: 17th annual meeting of the organization on Human Brain Mapping
  • Place of Presentation: Quebec City, Canada
  • Year and Date: 2011-06-29
• [Presentation] Comprehensive retinotopic mapping by fMRI and direct cortical stimulation in occipital lobe epilepsy (2011)
  • Author(s): Shimotake A, Matsumoto R, Kanazu M, Yamamoto H, Yamao Y, Matsuhashi M, Sawamoto N, Mikuni N, Miyamoto S, Fukuyama H, et al.
  • Organizer: 17th annual meeting of the organization on Human Brain Mapping
  • Place of Presentation: Quebec City, Canada
  • Year and Date: 2011-06-29
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~neurology/