2013 Fiscal Year Final Research Report
A PET study for relation of adenosine receptors with involuntary movements in Parkinson's disease
| Project/Area Number |
23591287
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Masahiko 東京慈恵会医科大学, 医学部, 准教授 (20266638)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIWATA Kiichi 東京都健康長寿医療センター, 研究所, 研究部長 (50143037)
ISHII Kenji 東京都健康長寿医療センター, 研究所, 研究副部長 (10231135)
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| Project Period (FY) |
2011 – 2013
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| Keywords | パーキンソン病 / 安静時振戦 / 固縮 / アデノシンA1受容体 / アデノシンA2A受容体 / ドパミンD2受容体 / ドパミントランスポータ / PET |
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| Research Abstract |
At the dopaminergic synapse, the adenosine A1 receptors (A1Rs) negatively interacts with the dopamine D1 receptor (D1R) in direct pathway neurons and the adenosine A2A receptors (A2ARs) in indirect pathway neurons. The A1R is also found presynaptically, where it is involved in regulation of the dopaminergic system. In addition, the A2AR negatively interacts with the dopamine D2 receptor (D2R) in indirect pathway neurons. The aim of this study was to investigate relationship of striatal density of A1Rs, A2ARs, dopamine transporters (DATs) and D2Rs in resting tremor and rigidity in Parkinson's disease (PD) using positron emission tomography (PET). PET demonstrated significant correlation between the subscores and the density of DATs in the posterior putamen, but not the density of A1Rs, A2ARs and D2Rs. Our study suggested that tremor at rest and rigidity was involved in reduction of DAT in posterior putamen, but not showed the significant relationship with the density of A2AR and D2R.
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[Journal Article] Striatal Distribution of Dopamine Transporters and Dopamine D2 Receptors at Different Stages of Parkinson's Disease–A CFT and RAC PET Study2011
Author(s)
Mishina M, Ishii K, Suzuki M, Kitamura S, Ishibashi K, Sakata M, Oda K, Hamamoto M, Kominami S, Kobayashi S, Katayama Y, Ishiwata K
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Journal Title
The Neuroradiology Journal
Volume: 24(2)
Pages: 235-241
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[Journal Article] Adenosine A2A Receptors Measured with [^<11>C]TMSX PET in the Striata of Parkinson's Disease Patients2011
Author(s)
Mishina M, Ishiwata K, Naganawa M, Kimura Y, Kitamura S, Suzuki M, Hashimoto M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kobayashi S, Katayama Y, Ishii K
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Journal Title
PLoS One
Volume: 6:e17338
Pages: 1-8
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[Presentation] Relation of striatal density of adenosine A2A receptors, dopamine transporter and dopamine D2 receptor with tremor at rest and rigidity in Parkinson's disease2013
Author(s)
Mishina M, Ishii K, Suzuki M, Nagayama H, Kitamura S, Hashimoto M, Naganawa M, Kimura Y, Sakata M, Oda K, Toyohara J, Katayama Y, Ishiwata K
Organizer
The 17th International Congress of Parkinson's Disease and Movement Disorders
Place of Presentation
Sydney
Year and Date
20130616-20
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[Presentation] Evaluation of putaminal adenosine A1 receptors in drug naïve Parkinson's disease measured with [^<11>C]MPDX PET2012
Author(s)
Mishina M, Ishii K, Suzuki M, Kitamura S, Hashimoto M, Kimura Y, Sakata M, Oda K, Toyohara J, Kobayashi S, Katayama Y, Ishiwata K
Organizer
The 16th International Congress of Parkinson's Disease and Movement Disorders
Place of Presentation
Dublin
Year and Date
20120617-20
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