2013 Fiscal Year Final Research Report
Influence of chronic kidney disease on carotid atherosclerosis, stroke features, and outcomes of thrombolysis for acute stroke
| Project/Area Number |
23591288
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
TOYODA Kazunori 独立行政法人国立循環器病研究センター, 病院, 部門長 (50275450)
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| Co-Investigator(Kenkyū-buntansha) |
KOKUBO Yoshihiro 独立行政法人国立循環器病研究センター, 病院, 医長 (20393217)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳血管障害 / 慢性腎臓病 / 頸動脈硬化 / 脳腎連関 |
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| Research Abstract |
To determine associations between chronic kidney disease (CKD) and cerebrovascular diseases, in the other words cerebro-renal interaction, the following studies were performed. (1) In the Suita Study, an epidemiological study involving Japanese urban residents, the association of CKD with carotid atherosclerosis was modest, but CKD was independently associated with carotid atherosclerosis in hypertensive subjects. (2) In acute intracerebral hemorrhage patients, excessive reduction of systolic blood pressure was associated with acute worsening renal function. Worsening renal function was related to unfavorable clinical outcome. (3) In the multicenter study, renal dysfunction was independently associated with unfavorable outcomes in rt-PA-treated ischemic stroke patients and those in intracerebral hemorrhage patients. (4) An English review on cerebro-renal interaction was completed partly based on the current study results.
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[Journal Article] Reduced estimated glomerular filtration rate is associated with stroke outcomes after intravenous rt-PA : the Stroke Acute Management with Urgent Risk-factor Assessment and Improvement (SAMURAI) Study2011
Author(s)
Naganuma M, Koga M, Shiokawa Y, Nakagawara J, Furui E, Kimura K, Yamagami H, Okada Y, Hasegawa Y, Kario K, Okuda S, Nishiyama K, Minematsu K, Toyoda K
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Journal Title
Cerebrovasc Dis
Volume: 31
Pages: 123-129
Peer Reviewed
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