2013 Fiscal Year Final Research Report
Short-form GIP; Its Secretion and Glucose homeostasis
| Project/Area Number |
23591291
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONJO Jun 旭川医科大学, 内科学講座病態代謝内科学分野, 特任助教 (30451462)
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| Project Period (FY) |
2011 – 2013
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| Keywords | GIP / インクレチン / 膵島 / α細胞 |
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| Research Abstract |
GIP is an incretin hormone, which is released from the gut and involved in homeostasis of glucose metabolism though glucose-depedent insulin secretion from pancreatic beta cells. Interestingly, c-terminal truncated short-form GIP is expressed in pancreatic alpha cells. We found expanded short-from GIP expression in the islet of several diabetic animal models. We synthesized modified short-form GIP and confirmed the peptide to be biologically active by the administration to the normal mice. Finally we treated STZ induced diabetic mice with modified short-form GIP and observed the peptide showed potential to suppress the progression to chronic hyperglycemia in the diabetic model.
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