2013 Fiscal Year Final Research Report
Role of TBP-2 of pancreatic B cells in glucose intolerance
| Project/Area Number |
23591308
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Nobuya 京都大学, 医学研究科, 教授 (30241954)
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| Project Period (FY) |
2011 – 2013
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| Keywords | TBP-2 / 糖尿病 / B細胞 |
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| Research Abstract |
This study was designed to elucidate in vivo regulation of thioredoxin-binding protein 2 (TBP-2) and roles of TBP-2 in glucose intolerance. Disruption of TBP-2 in whole body ameliorates glucose level in ob/ob mouse, a model of obese diabetes. In B cell-specific TBP-2 transgenic mice, generated in this study, glucose tolerance was not altered, but B cell area was reduced, which suggests a role of TBP-2 in regulation of B cell mass. Treatment of ob/ob mice by hypoglycemic agents and high fat diet on normal mice reveled that hyperglycemia, not obese induced by high fat diet, plays a role in overexpression of TBP-2 in B cells in vivo.
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[Journal Article] Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction2013
Author(s)
Sasaki M, Fujimoto S, Sato Y, Nishi Y, Mukai E, Yamano G, Sato H, Tahara Y, Ogura K, Nagashima K, Inagaki N
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Journal Title
Diabetes
Volume: 62
Pages: 1996-2003
DOI
Peer Reviewed
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[Journal Article] Tetrahydro biopterin has a glucose-lowering effect by suppressing hepatic gluconeogenesis in an endothelial nitric oxide synthase- dependent manner in diabetic mice2013
Author(s)
Abudukadier A, Fujita Y, Obara A, Ohashi A, Fukushima T, Sato Y, Ogura M, Nakamura Y, Fujimoto S, Hosokawa M, Hasegawa H, Inagaki N
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Journal Title
Diabetes
Volume: 62
Pages: 3033-3043
DOI
Peer Reviewed
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[Journal Article] Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury2013
Author(s)
Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Horino T, Fujieda M, Fujimoto S, Terada Y
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Journal Title
Am J Physiol
Volume: 305
Pages: F495-F509
DOI
Peer Reviewed
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[Journal Article] Upregulation of HNF-1βduring experimental acute kidney injury plays a crucial role in renal tubule regeneration2012
Author(s)
Ogata K, Shimamura Y, Hamada K, Hisa M, Bun M, Okada N, Inoue K, Taniguchi Y, Ishihara M, Kagawa T, Horino T, Fujimoto S, Terada Y
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Journal Title
Am J Physiol
Volume: 303
Pages: F689-F699
DOI
Peer Reviewed
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[Journal Article] Liver X receptorαis involved in the transcriptional regulation of the 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase gene2012
Author(s)
Zhao LF, Iwasaki Y, Nishiyama M, Taguchi T, Tsugita M, Okazaki M, Nakayama S, Kambayashi M, Fujimoto S, Hashimoto K, Murao K, Terada Y
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Journal Title
Diabetes
Volume: 61
Pages: 1062-1071
DOI
Peer Reviewed
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[Presentation] Palmitate induces ROS production andβ-cell dysfunction by activating NADPH oxidase via Src signaling, American Diabetes Association2013
Author(s)
Sato Y, Fujimoto S, Mukai E, Sato H, Tahara Y, Ogura K, Yamano G, Ogura M, Nagashima K, Seino Y, Inagaki N
Organizer
73rd Scientific Sessions
Place of Presentation
Moscone Center, Chicago, IL, USA
Year and Date
2013-06-23
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[Presentation] Persistent reduction of ROS ameliorates metabolism-secretion coupling in cultured diabetic GK Islets by suppressing Warburg effect2012
Author(s)
Sasaki M, Fujimoto S, Nishi Y, Mukai E, Yamano G, Sato Y, Sato H, Tahara Y, Ogura K, Nagashima K, Inagaki N
Organizer
American Diabetes Association, 72nd Scientific Sessions
Place of Presentation
McCormick Place Convention Center, Philadelphia, PA, USA
Year and Date
2012-06-10
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