2013 Fiscal Year Final Research Report
Clarification of pathogenetic mechanisms of type 1 diabetes and its adaptation to prediction and prevention
| Project/Area Number |
23591310
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Nagasaki University |
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Principal Investigator |
KAWASAKI Eiji 長崎大学, 大学病院, 准教授 (70336171)
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| Co-Investigator(Renkei-kenkyūsha) |
ABIRU Norio 長崎大学, 医歯薬学総合研究科, 准教授 (00380981)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 1型糖尿病 / 自己抗体 / 自己抗原 / 亜鉛 / エピトープ / 診断 / ラジオイッムノアッセイ / 病型 |
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| Research Abstract |
In order to examine the clinical significance of ZnT8 autoantibodies in type 1 diabetes, six ZnT8/ZnT3 chimeric cDNA were created and ZnT8 autoantibody epitopes were analyzed. As a result, the carboxy-terminal 10 amino acid residues in ZnT8 contribute to conformational epitope(s) that is associated with acute-onset and younger-onset type 1 diabetes.
Although prevalence of ZnT8 autoantibodies was higherin acute-onset or younger-onset patients at disease onset, it persisted in adult-onsetpatients.
Furthermore, we have evaluated a newly developed ZnT8 autoantibody ELISA.
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[Journal Article] Sequential elevation of autoantibodies to thyroglobulin and glutamic acid decarboxylase in type 1 diabetes2013
Author(s)
Kawasaki E, Yasui J, Tsurumaru M, Takashima H, Ikeoka T, Mori F, Akazawa S, Ueki I, Kobayashi M, Kuwahara H, Abiru N, Yamasaki H, Kawakami A
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Journal Title
World J Diabetes
Volume: 4
Pages: 227-230
Peer Reviewed
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[Journal Article] Type 1 diabetes and interferon therapy : A nationwide survey in Japan2011
Author(s)
Nakamura K, Kawasaki E, Imagawa A, Awata T, Ikegami H, Uchigata Y, Kobayashi T, Shimada A, Nakanishi K, Makino H, Maruyama T, Hanafusa T
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Journal Title
Diabetes Care
Volume: 34
Pages: 2084-2089
Peer Reviewed
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[Journal Article] Zinc transporter 8 autoantibodies in fulminant, acute-onset, and slow-onset patients with type 1 diabetes2011
Author(s)
Kawasaki E, Nakamura K, Kuriya G, Satoh T, Kobayashi M, Kuwahara H, Abiru N, Yamasaki H, Matsuura N, Miura J, Uchigata Y, Eguchi K
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Journal Title
Diabetes Metab Res Rev
Volume: 27
Pages: 895-898
Peer Reviewed
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[Presentation] Different kinetics of autoantibodies to insulin granule membrane autoantigens2011
Author(s)
Kawasaki E, Yasui J, Morokuma H, Ikeoka T, Murata F, Akazawa S, Ueki I, Nakamura K, Kobayashi M, Kuwahara H, Abiru N, Yamasaki H, Kawakami A
Organizer
IA-2 and ZnT8, after clinical onset of type 1 diabetes, 16th Japan-Korea Symposium on Diabetes Mellitus
Place of Presentation
千葉県浦安市(一般演題)
Year and Date
2011-10-21
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