2013 Fiscal Year Final Research Report
Study of the new insulin action in the peripheral tissues
| Project/Area Number |
23591313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | インスリン / 糖代謝 / シグナル伝達 / 糖尿病 |
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| Research Abstract |
Gut is the tissue that is important to glucose metabolism, but it is not clear about the insulin action to gut. Therefore applicants generated the gut-specific insulin acceptor knockout (IR gutKO) mice and analyzed influence on glucose metabolism.
Because IR gutKO mice showed impaired glucose tolerance in the glucose tolerance test, it was revealed that the insulin action to gut played an important role in glucose metabolism. In addition, expressions of many genes concerned with immunoreaction were changed in the duodenum of the IR gutKO mice by the result of the DNA micro array analysis. These results suggest that an enteric insulin signal modulate immune system and change intestinal flora, thereby controlling glucose metabolism.
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