• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Pancreatic beta-cell maintenance by parasympathetic nerve

Research Project

  • PDF
Project/Area Number 23591315
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionYokohama City University

Principal Investigator

ITO Yuzuru  横浜市立大学, 医学部, 助教 (00512980)

Co-Investigator(Kenkyū-buntansha) TERAUCHI Yasuo  横浜市立大学, 医学研究科, 教授 (40359609)
Project Period (FY) 2011 – 2013
Keywords膵β細胞 / アセチルコリン / GLP-1
Research Abstract

We investigated the molecular mechanism of acetylcholine which was the major neurotransmitter of the parasympathetic nerve, in pancreatic beta-cell maintenance. Pancreatic beta-cell proliferation was caused by the acetylcholine administration in pancreatic beta-cell line (MIN6) and mouse. It is known that the molecules such as IRS-2, Akt and MAPkinase, make the important role in mechanism of pancreatic beta-cell proliferation. However, acetylcholine was able to stimulate the pancreatic beta-cell proliferation independently of these molecules. GLP-1 secretion was increased by the acetylcholine administration in mouse. It was suggested that acetylcholine caused beta-cell proliferation through GLP-1.

  • Research Products

    (17 results)

All 2014 2013 2012 2011

All Journal Article (15 results) (of which Peer Reviewed: 13 results) Presentation (2 results)

  • [Journal Article] 最新肥満症候学V.症候性肥満の成因と病態インスリノーマ2014

    • Author(s)
      伊藤譲,寺内康夫
    • Journal Title

      日本臨床

      Volume: 72 Pages: 342-346

  • [Journal Article] Glycemic control after addition of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes showing inadequate response to thrice-a day treatment withα-glucosidase inhibitors2013

    • Author(s)
      Masuda K, Aoki K, Kamiko K, Takihata M, Ito Y, Nagakura M, Kawasaki S, Akema N, Hasegawa M, Nakajima S, Toumura S, Tsunoda S, Enomoto H, Shimotomai H, Terauchi, Y
    • Journal Title

      Expert Opinion on Pharmacotherapy

      Volume: 14(9) Pages: 1111-8

    • DOI

      10.1517/14656566.2013.790365

    • Peer Reviewed
  • [Journal Article] AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration2013

    • Author(s)
      Tajima K, Shirakawa J, Togashi Y, Inoue H, Sato K, Orime K, Ito Y, Kaji M, Sakamoto E, Nakamura A, Aoki K, Goshima Y, Atsumi T, Terauchi, Y
    • Journal Title

      PLoS One

      Volume: 8(5) Pages: e64633

    • DOI

      10.1371/journal.pone.0064633

    • Peer Reviewed
  • [Journal Article] Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 Mice.2013

    • Author(s)
      Tajima K, Nakamura A, Shirakawa J, ogashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi, Y
    • Journal Title

      Am. J. Physiol Endocrinol. Metab

      Volume: 305 Pages: E987-98

    • DOI

      10.1152/ajpendo.00133

    • Peer Reviewed
  • [Journal Article] Trefoil Factor 2 Promotes Cell Proliferation in Pancreaticβ-Cells through CXCR-4-Mediated ERK1/2 Phosphorylation2013

    • Author(s)
      Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi, Y
    • Journal Title

      Endocrinology

      Volume: 154(1) Pages: 54-64

    • DOI

      10.1210/en.2012-1814

    • Peer Reviewed
  • [Journal Article] KEYWORD SREBP脂肪肝や糖インスリン代謝など生活習慣病に深くかかわる2012

    • Author(s)
      伊藤譲,寺内康夫
    • Journal Title

      Cardio-Lipidology

      Volume: 6 Pages: 80-83

  • [Journal Article] Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance, beta cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet2012

    • Author(s)
      Sato K, Nakamura A, Shirakawa J, Muraoka T, Togashi Y, Shinoda K, Orime K, Kubota N, Kadowaki T, Terauchi, Y
    • Journal Title

      Endocrinology

      Volume: 153 Pages: 1093-1102

    • DOI

      10.1210/en.2011-1712

    • Peer Reviewed
  • [Journal Article] Control of beta cell function and proliferation in mice stimulated by small molecule glucokinase activator under various conditions2012

    • Author(s)
      Nakamura A, Togashi Y, Orime K, Sato K, Shirakawa J, Ohsugi M, Kubota N, Kadowaki T, Terauchi, Y
    • Journal Title

      Diabetologia

      Volume: 55(6) Pages: 1745-54

    • DOI

      10.1007/s00125-012-2521-5

    • Peer Reviewed
  • [Journal Article] Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes2012

    • Author(s)
      Shirakawa J, Togashi Y, Tajima K, Orime K, Kikuchi K, Miyazaki T, Sato K, Kimura M, Goshima Y, Terauchi Y
    • Journal Title

      Diabetes Res. Clin. Pract.

      Volume: 97(1) Pages: e7-e10

    • DOI

      10.1016/j.diabres.2012.03.017

    • Peer Reviewed
  • [Journal Article] Effects of liraglutide onβcell-specific glucokinase-deficient neonatal mice2012

    • Author(s)
      Shirakawa J, Tanami R, Togashi Y, Tajima K, Orime K, Kubota N, Kadowaki T, Goshima Y, Terauchi, Y
    • Journal Title

      Endocrinology

      Volume: 153(7) Pages: 3066-75

    • DOI

      10.1210/en.2012-1165

    • Peer Reviewed
  • [Journal Article] Protection from nonalcoholic steatohepatitis and liver tumorigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance2012

    • Author(s)
      Nakamura A, Tajima K, Zolzaya K, Sato K, Inoue R, Yoneda M, Fujita K, Nozaki Y, Kubota KC, Haga H, Kubota N, Nagashima Y, Nakajima A, Maeda S, Kadowaki T, Terauchi, Y
    • Journal Title

      Diabetologia

      Volume: 55 Pages: 3382-91

    • DOI

      10.1007/s00125-012-2703-1

    • Peer Reviewed
  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle2011

    • Author(s)
      Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
    • Journal Title

      Cell Metab

      Volume: 13 Pages: 294-307

    • DOI

      10.1016/j.cmet.2011.01.018

    • Peer Reviewed
  • [Journal Article] Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice2011

    • Author(s)
      Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E and Terauchi, Y
    • Journal Title

      Diabetes

      Volume: 60(4) Pages: 1246-57

    • DOI

      10.2337/db10-1338

    • Peer Reviewed
  • [Journal Article] Protective effect of a dipeptidyl peptidase-4 (DPP-4) inhibitor against increasedβcell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes2011

    • Author(s)
      Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi, Y
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 25467-76

    • DOI

      10.1074/jbc.M110.217216

    • Peer Reviewed
  • [Journal Article] Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet2011

    • Author(s)
      Muraoka T, Aoki K, Iwasaki T, Shinoda K, Nakamura A, Aburatani H, Mori S, Tokuyama K, Kubota N, Kadowaki T, Terauchi Y
    • Journal Title

      Metabolism

      Volume: 60 Pages: 617-28

    • DOI

      10.1016/j.metabol.2010.06.008

    • Peer Reviewed
  • [Presentation] 妊娠糖尿病にてインスリン治療が必要となった症例の臨床背景に関する検討2013

    • Author(s)
      伊藤譲,澁谷誠,吉村公一郎,細川紗帆,山本葉子,永田亮,杉浦賢,寺内康夫
    • Organizer
      第56回日本糖尿病学会学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-18
  • [Presentation] 副交感神経伝達物質による膵β細胞機能制御の解析2011

    • Author(s)
      伊藤譲,白川純,田波律子,折目和基,瀧端正博,田島一樹,宮崎岳之,佐藤光一郎,菊地香織,増田清美,村岡知則,富樫優,中村昭伸,土屋博久,澁谷誠,木村真理,寺内康夫
    • Organizer
      第54回日本糖尿病学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-20

URL: 

Published: 2015-07-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi