The pathogenetic role of Salusin-beta in diabetic nephropathy

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591322
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kitasato University
• Principal Investigator: MORIYA TATSUMI 北里大学, 医学部, 教授 (50191052)
• Co-Investigator(Kenkyū-buntansha): TAKADA Tesshu 北里大学, 医学部, 助教 (60276144)
• Co-Investigator(Renkei-kenkyūsha): SHICHIRI Masayoshi 北里大学, 医療系研究科, 教授 (10206097)
• Project Period (FY): 2011 – 2013
• Keywords: 糖尿病性腎症

Research Abstract

We evaluated the Salusin-beta in 28 normal controls (C), 10 type 1 diabetic patients (T1) and 66 type 2 diabetic patients (T2) to elucidate its pathogenetic roles on diabetic nephropathy. Plasma concentration of Salusin-beta did not differ among 3 groups (C; 4.11+/-1.68 nmol/l, T1; 4.71+/-2.04, T2; 4.40+/-1.87). In all diabetic subjects, there was no significant difference of Salusin-beta between 58 normoalbuminuria (4.44+/-1.90 nmol/l) and microalbuminuria (4.42+/-1.89). Salusin-beta did not correlate with GFR measured using iohexol injection. There was no significant difference of Salusin-beta between hyperfiltration or normofiltration. In the cross-sectional study, there was no relationships between Salusin-beta and renal functional changes, i.e. albuminuria or GFR in Japanese diabetic patients. Further longitudinal study is warranted to elucidate its pathogenetic roles on diabetic nephropathy.

Research Products

• [Journal Article] Circulating levels of human salusin-β, a potent hemodynamic and atherogenesis regulator (2013)
  • Author(s): Fujimoto K, Hayashi A, Kamata Y, Ogawa A, Watanabe T, Ichikawa R, Iso Y, Koba S, Kobayashi Y, Koyama T, Shichiri M
  • Journal Title: PLoS One Volume: 8(10) Pages: e76714
  • DOI: 10.1371/journal.pone.0076714.eCollection2013
  • Peer Reviewed
• [Journal Article] Serum monomericα2-macroglobulin as a clinical biomarker in diabetes (2013)
  • Author(s): Takada T, Kodera Y, Matsubara M, Kawashima Y, Maeda T, Fujita Y, Shichiri M
  • Journal Title: Atherosclerosis Volume: 228(1)(Epub 2013 Mar 13) Pages: 270-6
  • DOI: 10.1016/j.atherosclerosis.2013.02.035
  • Peer Reviewed
• [Journal Article] Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes (2013)
  • Author(s): Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H; The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan
  • Journal Title: Clin Exp Nephrol Volume: (Epub ahead of print)
  • DOI: 10.1007/s10157-013-0879-4
  • Peer Reviewed
• [Journal Article] Association between remission of macroalbuminuria and preservation of renal function in patients with type 2 diabetes with overt proteinuria (2013)
  • Author(s): Yokoyama H, Araki S, Honjo J, Okizaki S, Yamada D, Shudo R, Shimizu H, Sone H, Moriya T, Haneda M
  • Journal Title: Diabetes Care Volume: 36(10)(Epub 2013 Jun 18) Pages: 3227-33
  • DOI: 10.2337/dc13-0281
  • Peer Reviewed
• [Journal Article] Diabetic retinopathy and microalbuminuria can predict macroalbuminuria and renal function decline in Japanese type 2 diabetic patients : Japan Diabetes Complications Study (2013)
  • Author(s): Moriya T, Tanaka S, Kawasaki R, Ohashi Y, Akanuma Y, Yamada N, Sone H, Yamashita H, Katayama S; Japan Diabetes Complications Study Group
  • Journal Title: Diabetes Care Volume: 36(9)(Epub 2013 Apr 25) Pages: 2803-9
  • DOI: 10.2337/dc12-2327
  • Peer Reviewed
• [Journal Article] Glomerular hyperfiltration and increased glomerular filtration surface are associated with renal function decline in normo- and microalbuminuric type 2 diabetes (2012)
  • Author(s): Tatsumi Moriya, Akiko Tsuchiya, Shin-ichiro Okizaki, Akinori Hayashi, Keiji Tanaka and Masayoshi Shichiri
  • Journal Title: Kidney International Volume: 81 Pages: 486-493
  • DOI: 10.1038/ki.2011.404
  • Peer Reviewed
• [Journal Article] Relationship between a Low Ankle Brachial Index and All-Cause Death and Cardiovascular Events in Subjects with and without Diabetes
  • Author(s): Yokoyama H, Sone H, Honjo J, Okizaki S, Yamada D, Shudo R, Shimizu H, Moriya T, Haneda A
  • Journal Title: J Atheroscler Thromb Volume: (Epub ahead of print) Pages: 2014
  • Peer Reviewed
• [Presentation] Renal histological heterogeneity and functional progress in normo- and microalbuminuric Japanese type 2 diabetic patients (2013)
  • Author(s): Moriya T., Suzuki Y., Inomata S., Iwano M., Haneda M.
  • Organizer: 73^<rd> Scientific Sessions (2013), American Diabetes Association
  • Place of Presentation: シカゴ、アメリカ
  • Year and Date: 20130622-24