2013 Fiscal Year Final Research Report
Identification and characterization of susceptibility genes for type 1 diabetes in the major histocompatibility complex
| Project/Area Number |
23591328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEGAMI Hiroshi 近畿大学, 医学部, 教授 (20221062)
NOUSOU Shinsuke 近畿大学, 医学部, 講師 (90460849)
BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 1型糖尿病 / 遺伝子 / HLA |
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| Research Abstract |
To clarify genetic susceptibility to type 1 diabetes in the major histocompatibility complex , we robustly investigated the association of HLA-DRB1, DQB1, A, B, C loci with type 1 diabetes. This study showed that the frequency of the combination of DRB1*04:05-DQB1*04:01 and DRB1*08:02-DQB1*03:02 was low in Japanese population, but this was very high risk combination to type 1 diabetes. Several alleles of B, C loci were associated with type 1 diabetes, but most of them appeared to be secondary to linkage disequilibrium between these alleles and disease-related class II alleles. Taken the result with autoimmune thyroid disease in consideration, these data suggest that HLA Class II and Class I might contribute to the genetic susceptibility in the different manner, for each specific target organ.
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