2013 Fiscal Year Final Research Report
Obesity, atherosclerosis and RAGE-mediated inflammatory signal
| Project/Area Number |
23591329
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMOTO Shinya 大阪市立大学, 大学院医学研究科, 講師 (90381996)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Hiroshi 金沢大学, 大学院医学系研究科, 教授 (00115198)
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| Research Collaborator |
RAINES Elaine W. University of Washington, Department of Pathology, Professor
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| Project Period (FY) |
2011 – 2013
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| Keywords | 終末糖化産物受容体(RAGE) / 肥満 / メタボリックシンドローム / インスリン抵抗性 / 糖尿病 / 可溶性RAGE(ｓRAGE) / 分泌型RAGE(esRAGE) |
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| Research Abstract |
Receptor for advanced glycation end-products (RAGE) is deeply involved in pathogenesis of chronic diabetic vascular complications including nephropathy and atherosclerosis. In this research project, we have found that RAGE plays important roles in etiology of obesity, metabolic syndrome, and insulin resistance by using in vitro adipogenesis model system and in vivo obesity mouse model (Diabetes 2013). In clinical research, we have also found that thiazolidinediones have profound effects on RAGE system, by directly comparing with sulfonyurea in a randomized controlled trial (Atherosclerosis 2014).
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[Journal Article] Comparison of effects of pioglitazone and glimepiride on plasma soluble RAGE and RAGE expression in peripheral mononuclear cells in type 2 diabetes : Randomized controlled trial (PioRAGE)2014
Author(s)
Koyama H, Tanaka S, Monden M, Shoji T, Morioka T, Fukumoto S, Mori K, Emoto M, Shoji T, Fukui M, Fujii H, Nishizawa Y, Inaba M
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Journal Title
Atherosclerosis
Volume: 234
Pages: 329-334
Peer Reviewed
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[Journal Article] Receptor for advanced glycation end-products (RAGE) regulates adipocyte hypertrophy and insulin sensitivity in mice : involvement of Toll-like receptor 22013
Author(s)
Monden M, Koyama H, Otsuka Y, Morioka T, Mori K, Shoji T, Mima Y, Motoyama K, Fukumoto S, Shioi A, Emoto M, Yamamoto H, Nishizawa Y, Kurajoh M, Yamamoto T, Inaba M
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Journal Title
Diabetes
Volume: 62
Pages: 478-489
Peer Reviewed
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