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2013 Fiscal Year Final Research Report

Physiological diversity of cytosolic T3 binding protein.: Relationship between inflammation and low T3 syndrome

Research Project

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Project/Area Number 23591349
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionFukushima Medical University (2013)
Shinshu University (2011-2012)

Principal Investigator

SUZUKI Satoru  福島県立医科大学, 医学部, 教授 (30222061)

Project Period (FY) 2011 – 2013
Keywords甲状腺ホルモン / ホルモン輸送 / 細胞質 / クリスタリン / NADPH
Research Abstract

1. To elucidate the mechanisms of its expression, we evaluated the promoter transactivity and insulin signaling via the AP-1 site in the promoter.The results indicated that the expression of mu-crystallin was regulated through the AP-1 site in the promoter. The signals related to AP-1 activation, such as insulin signaling may have diverse effects on mu-crystallin mRNA expression. .
2.To examine the precise regulation of T3-responsive genes in the presence of CRYM, we evaluated serial alterations of T3-responsive gene expression by changing pericellular T3 concentrations in the media.The results suggest that CRYM expression increases and sustains the T3 responsiveness of genes in cells, especially with alteration of the pericellular T3 concentration.

  • Research Products

    (9 results)

All 2014 2013 2012 2011

All Journal Article (2 results) Presentation (7 results)

  • [Journal Article] Cytosolic T3-binding protein modulates dynamic alteration of T3-mediated gene expression in cells2014

    • Author(s)
      Takeshige K, Sekido T, Kitahara JI, Ohkubo Y, Hiwatashi D, Ishii H, Nishio SI, Takeda T, Komatsu M, Suzuki S
    • Journal Title

      Endocr J

      Volume: (Epau ahead of print)

  • [Journal Article] Possible Roles of the AP-1 Site in the Cytosolic T3 Binding Protein Promoter and Insights into its Physiological Significance2013

    • Author(s)
      Suzuki S, Nishio SI, Ishii H, Sekido T, Takeshige K, Ohkubo Y, Hiwatashi D,Takeda T, Komatsu M
    • Journal Title

      Horm Metab Res

      Volume: 45 Pages: 501-506

  • [Presentation] 糖尿病における細胞質甲状腺ホルモン結合蛋白(CRYM)の発現変化について2012

    • Author(s)
      関戸貴志、大久保洋輔、竹重恵子、樋渡大、石井宏明、西尾真一、武田貞二、鈴木悟、駒津光久
    • Organizer
      第55回日本甲状腺学会
    • Place of Presentation
      福岡
    • Year and Date
      20121129-1201
  • [Presentation] 細胞質甲状腺ホルモン結合蛋白(CRYM)による甲状腺ホルモン応答遺伝子発現様式の細胞レベルでの変化について2012

    • Author(s)
      竹重恵子、関戸貴志、大久保洋輔、樋渡大、石井宏明、西尾真一、武田貞二、鈴木悟、駒津光久
    • Organizer
      第55回日本甲状腺学会
    • Place of Presentation
      福岡
    • Year and Date
      20121129-1201
  • [Presentation] 糖尿病における細胞質甲状腺ホルモン結合蛋白質(CRYM)の発現変化について2012

    • Author(s)
      鈴木悟、西尾真一、武田貞二、駒津光久
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      20120419-21
  • [Presentation] カーボンナノチューブと組み換えアデノウイルスを用いた未分化甲状腺癌に対する遺伝子治療2012

    • Author(s)
      武田貞二、西尾真一、山崎雅則、鈴木悟、駒津光久
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      20120419-21
  • [Presentation] 男性において、甲状腺ホルモン抵抗性は加齢により軽減する2011

    • Author(s)
      鈴木悟、西尾真一、石井宏明、武田貞二、駒津光久
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      20111121-23
  • [Presentation] 数理モデルを用いた年齢依存性甲状腺ホルモン抵抗性について2011

    • Author(s)
      鈴木悟、西尾真一、武田貞二、駒津光久
    • Organizer
      第53回老年医学会
    • Place of Presentation
      東京
    • Year and Date
      20110615-17
  • [Presentation] 糖尿病における細胞質甲状腺ホルモン結合蛋白質(CRYM)の発現について2011

    • Author(s)
      鈴木悟、西尾真一、武田貞二、駒津光久
    • Organizer
      第53回糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      20110519-21

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Published: 2015-07-16  

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