2014 Fiscal Year Final Research Report
Identification and functional analysis of novel markers for thyroid cancer stem cells
Project/Area Number |
23591357
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | Nagasaki University |
Principal Investigator |
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Keywords | 甲状腺 / 癌幹細胞 |
Outline of Final Research Achievements |
Cancer stem-like cells (CSCs) play important roles in cancer initiation, recurrence, and metastasis. In the present study, we conducted a comprehensive search for thyroid CSC markers. Expression of cell surface markers and ALDH activity, which are CSC markers in various solid cancers, and the ability to form spheres in vitro as an indicator of tumor-initiating ability were investigated using thyroid cancer cell lines. As a result, ALDH activity seems to be a major candidate marker for thyroid CSCs but not universal. Other markers such as CD326 and CD44 may be important depending on individual cases.
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Free Research Field |
内分泌腫瘍学
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