2013 Fiscal Year Final Research Report
Mining of novel granin-derived bioactive peptides that regulate insulin secretion.
| Project/Area Number |
23591358
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOSHINAI Koji 宮崎大学, 医学部, 講師 (80381101)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 生理活性ペプチド / 糖尿病 / インスリン / 膵β細胞 |
|---|
| Research Abstract |
To explore the physiological roles of NERP-2 in the pancreas, we examined its effects on insulin secretion. We detected NERP-2 immunoreactivity in pancreatic islets, where it co-localized extensively with insulin. NERP-2 increased glucose-stimulated insulin secretion (GSIS) in a dose-dependent manner from isolated mouse pancreatic islets. NERP-2 significantly augmented GSIS after administration to rodents. Neither NERP-1 nor NERP-2-Gly (non-amidated NERP-2) stimulated insulin secretion. Calcium-imaging analysis demonstrated that NERP-2 increased the calcium influx in MIN6 cells. These findings show that NERP-2 is a novel bioactive peptide to stimulate insulin secretion.
|
-
-
-
[Journal Article] Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro2012
Author(s)
Yamaguchi H, Moin AH, Rhee M ,Kim JW, Toshinai K, Waise TMZ, Naznin F, Matsuo T, Sasaki K, Minamino N, Yoon KH, Nakazato M
-
Journal Title
Biochem Biophys Res Commun
Volume: 428
Pages: 512-517
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
