Functional analysis of transcription factors regulating brain-spesific expression of aromatase gene

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591360
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Fukuoka University
• Principal Investigator: HONDA Shin-ichiro 福岡大学, 薬学部, 准教授 (40257639)
• Project Period (FY): 2011 – 2013
• Keywords: 転写因子 / 転写制御 / 性分化

Research Abstract

Steroid hormones act reversibly or irreversibly in every developmental stage. With regard to the biological environmental adaptation of an organism, the action of the steroid is one of the most interesting phenomena. The steroid hormones take important role that is to function expression of central nervous system. In rodents, the substantial sex differences of the brain are performed by estrogen action in a perinatal period. Meanwhile, since the expression of aromatase gene increases transiently in a perinatal period, it is conceivable that the program of the transcriptional regulation of aromatase gene is deeply concerned with the sexual differentiation of the brain. In this study, to elucidate of the sex differentiation of the brain, I analyzed the transcription factors that take part in the control of the brain-specific expression of the aromatase gene.

Research Products

• [Journal Article] LIM-homeodomain transcription factor, Lhx2, is involved in transcriptional control of brain-spescific promoter / exon 1f of the mouse aromatase gene (2012)
  • Author(s): Honda, S., Kozako, T., Shimeno, H., Soeda, S., & Harada, N.
  • Journal Title: Journal of neuroendocrinology Volume: Vol.24 Pages: 1367-1374
  • DOI: 10.1111/j.1365-2826.2012.02356.x
  • Peer Reviewed
• [Journal Article] Behavioral analysis of genetically modified mice indicates essential roles of neuro- steroidal estrogen (2011)
  • Author(s): Honda, S-I., Wakatsuki, T., & Harada, N.
  • Journal Title: Frontiers in Endocrinology Volume: Vol.2, article 40
  • DOI: 10.3389/fendo.201100040
  • Peer Reviewed
• [Presentation] Deaf1タンパク質の機能ドメインの解析 (2014)
  • Author(s): 本田伸一郎、原田信広、小迫知弘、相川晃慶、坂田晃、添田秦司
  • Organizer: 第134回日本薬学会年会
  • Place of Presentation: 熊本
  • Year and Date: 2014-03-30
• [Presentation] アロマターゼの脳特異的発現に関与する転写因子Deaf-1の機能ドメインの解析 (2012)
  • Author(s): 本田伸一郎、大下遥子、民本愛、小迫知弘、蔵元佑嘉子、元流梨恵、原田信広、添田秦司
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] アロマターゼの脳特異的プロモーター結合因子の解析 (2011)
  • Author(s): 大下遥子、本田伸一郎、小迫知弘、蔵元佑嘉子、元流梨恵、原田信広、添田秦司、占野廣司
  • Organizer: 第39回薬物活性シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-21
• [Presentation] 発生工学的手法を用いた脳内アロマターゼの機能解析 (2011)
  • Author(s): 民本愛、本田伸一郎、小迫知弘、蔵元佑嘉子、元流梨恵、原田信広、添田秦司、占野廣司
  • Organizer: 第39回薬物活性シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-21
• [Presentation] 脳特異的なアロマターゼ発現に関与するDeaf-1タンパク質の機能解析 (2011)
  • Author(s): 原口美紀、古田展也、安田千穂、本田伸一郎、小迫知弘、蔵元佑嘉子、元流梨恵、原田信広、占野廣司、添田秦司
  • Organizer: 日本生化学会九州支部例会
  • Place of Presentation: 久留米
  • Year and Date: 2011-05-22
• [Book] Molecular Mechanisms Controlling Brain Aromatase Expression. BRAIN AROMATASE ESTROGENS AND BEHAVIOR(Chapter 8) (2012)
  • Author(s): Harada, N. and Honda, S.
  • Publisher: OXFORD UNIVERSITY PRESS(ISBN : 978-0-19-84119-6)