2013 Fiscal Year Final Research Report
Investigation for the role of UBE2E2 in insulin secretory machinery and its molecular mechanisms
| Project/Area Number |
23591361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MINAKO Imamura 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (00596124)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Shiro 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (50314159)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 2型糖尿病 / 遺伝要因 |
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| Research Abstract |
We have evaluated the insulin secretion from pancreatic beta-cell line and phenotype of the genetically- modified mice for Ube2e2 to explore the role of UBE2E2 in pancreatic beta-cells. Our results indicate that it is important to consider the influence of environmental factor(s), such as age and obesity, to reveal the mechanism(s) how UBE2E2 contribute to conferring susceptibility to type 2 diabetes. We have also identified several candidates for causal variants by a fine- mapping within the UBE2E2 locus.
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[Journal Article] Assessing the clinical utility of a genetic risk score constructed using 49 susceptibility alleles for type 2 diabetes in a Japanese population2013
Author(s)
Imamura M, Shigemizu D, Tsunoda T, Iwata M, Maegawa H, Watada H, Hirose H, Tanaka Y, Tobe K, Kaku K, Kashiwagi A, Kawamori R, Maeda S
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Journal Title
J Clin Endocrinol Metab
Volume: 98(10)
Pages: E1667-73
DOI
Peer Reviewed
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[Journal Article] Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population2013
Author(s)
Imamura M, Iwata M, Maegawa H, Watada H, Hirose H, Tanaka Y, Tobe K, Kaku K, Kashiwagi A, Kadowaki T, Kawamori R and Maeda S
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Journal Title
J Diabetes Invest
Volume: Volume 4 Issue 2
Pages: 168-173
DOI
Peer Reviewed
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[Journal Article] Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population2011
Author(s)
Imamura M, Iwata M, Maegawa H, Watada H, Hirose H, Tanaka Y, Tobe K, Kaku K, Kashiwagi A, Kawamori R, Nakamura Y, Maeda S
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Journal Title
Diabetologia
Volume: 54(12)
Pages: 3071-7
DOI
Peer Reviewed
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