2013 Fiscal Year Final Research Report
Role of leptin in the pathogenesis of multiple myeloma
| Project/Area Number |
23591372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Naohide 東京大学, 医科学研究所, 教授 (90174680)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血液腫瘍学 / 骨髄腫 / レプチン / 臍帯血 / 細胞傷害性T細胞 |
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| Research Abstract |
We have focused on immunological aspect of leptin as a proinflammatory cytokine, and clarified the possible role of leptin on survival of murine myeloma cells with consideration of the bone marrow microenvironment. We further aimed to explore the role of leptin in the pathogenesis of human multiple myeloma, however difficulties associated with invasiveness of bone marrow aspiration obliged us to explore clinical use of umbilical cord blood as available and prominent source of immune cells alternatively. We have successfully isolated and expanded cytotoxic T lymphocytes(CTLs) from umbilical cord blood, as well as induced their HLA-restricted hematological tumor antigen specificity using beads coated with immunological molecules as artificial antigen presenting cells(aAPCs). This new method could potentially be applied clinically as new therapeutic strategy for not only multiple myeloma but also other hematological malignancies.
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