2013 Fiscal Year Final Research Report
Pathogenesis of hematological malignancies caused by viral infection
| Project/Area Number |
23591391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 造血器腫瘍 / ウイルス |
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| Research Abstract |
Some virus infections are closely associated with oncogenesis. In 2008, Merkel cell polyomavirus (MCPyV) was reported as the first tumor polyomavirus. The association of MCPyV with chronic lymphocytic leukemia (CLL) has been discussed in the Western world, whereas the prevalence of the virus in CLL cases in Eastern countries has not been investigated. In this study, we determined the prevalence and DNA loads of MCPyV in Japanese CLL cases. We found that MCPyV is present in a subset of Japanese CLL cases, but it is unclear that MCPyV have a direct causal role in Japanese CLL.
Since MCPyV can also infect monocytic cells, we investigated the prevalence of MCPyV in disorders of monocytic lineage. MCPyV DNA was not detected in any of our leukemia samples with the monocytic lineage, suggesting that MCPyV is unlikely to have played a pathogenetic role in the monocytic leukemias of these patients.
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Research Products
(32 results)
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[Journal Article] Hig h-throughput sequencing analysis of the chromosome 7q32 deletion revea ls IRF5 as a potential tumour suppr essor in splenic marginal-zone lymp homa2012
Author(s)
Fresquet V, Robles EF, Parker A, Ma rtinez-Useros J, Mena M, Malumbres R, Agirre X, Catarino S, Arteta D, Osaba L, Mollejo M, Hernandez-Rivas JM, Calasanz MJ, Daibata M, Dyer M J, Prosper F, Vizcarra E, Piris MA, Oscier D, Martinez-Climent JA
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Journal Title
British Journal of Haematology
Volume: 158
Pages: 712-726
DOI
Peer Reviewed
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[Journal Article] Inv olvement of KRAS G12A mutation in t he IL-2-independent growth of a hum an T-LGL leukemia cell line, PLT-22012
Author(s)
Mizutani N, Ito H, Hagiwara K, Koba yashi M, Hoshikawa A, Nishida Y, Ta kagi A, Kojima T, Suzuki M, Osawa Y, Ohishi K, Daibata M, Murate T
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Journal Title
Nagoya Journal of Medical Science
Volume: 74, (PMID : 2 3092099)
Pages: 261-271
Peer Reviewed
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