2013 Fiscal Year Final Research Report
Development of the new myeloma treatment based on the comprehensive analysis for genome structure abnormality and epigenome abnormality
| Project/Area Number |
23591399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
ISHIDA Tadao 札幌医科大学, 医学部, 准教授 (20305220)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Hiroshi 札幌医科大学, 道民医療推進学講座, 助教 (60570132)
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| Project Period (FY) |
2011 – 2013
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| Keywords | multiple myeloma / methylation / LINE-1 |
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| Research Abstract |
Global levels of the long interspersed nuclear element-1 (LINE-1) methylation declined with the degree of malignancy of plasma cells, and there was a significant inverse correlation between the degree of genomic loss and the LINE-1 methylation levels. Finally, there was a significant association between LINE-1 hypomethylation and poorer overall survival. Our findings suggest that global hypomethylation of LINE-1 may increase the malignant potential of myeloma cells by inducing broad copy-number losses.
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Research Products
(24 results)
