2013 Fiscal Year Final Research Report
The development of a novel monitoring method for early diagnosis of bronchiolitis obliterans after allo-HSCT
| Project/Area Number |
23591417
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANIMOTO Yasushi 南岡山医療センター, 臨床研究部・臨床研究, 部長 (60284098)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 閉塞性細気管支炎 / 特発性肺炎症候群 / 同種造血細胞移植 |
|---|
| Research Abstract |
Bronchiolitis obliterans syndrome is a devastating complication of allogeneic hematopoietic cell transplantation. A novel method for early diagnosis before it reaches an irreversible stage is required. We performed cytokine/chemokine analysis using serum, bronchoalveolar lavage fluid, and exhaled breath condensate of our patients. As a result, serum MIP-1 alpha, MIP-1 beta, TNF-alpha were selected as candidates of possible biomarkers for early diagnosis.
|
-
[Journal Article] Mammalian target of rapamycin inhibitors permit regulatory T cell reconstitution and inhibit experimental chronic graft-versus-host disease2014
Author(s)
Sugiyama H, Maeda Y, Nishimori H, Yamasuji Y, Matsuoka K, Fujii N, Kondo E, Shinagawa K, Tanaka T, Takeuchi K, Teshima T, Tanimoto M
-
Journal Title
Biol Blood Marrow Transplant
Volume: 20(2)
Pages: 183-91
Peer Reviewed
-
[Journal Article] Bronchiolitis obliterans with allogeneic hematopoietic cell transplantation : a 10-year experience of the Okayama BMT Group2014
Author(s)
Fujii N, Nakase K, Asakura S, Matsuo K, Nawa Y, Sunami K, Nishimori H, Matsuoka K, Kondo E, Maeda Y, Shinagawa K, Hara M, Tanimoto M
-
Journal Title
Int J Hematol
Volume: 99(5)
Pages: 644-51
Peer Reviewed
-
[Journal Article] Complete resolution of steroid-resistant organizing pneumonia associated with myelodysplastic syndrome following allogeneic hematopoietic cell transplantation2014
Author(s)
Asano T, Fujii N, Niiya D, Nishimori H, Fujii K, Matsuoka K-I, Ichimura K, Hamada T, Kondo E, Maeda Y, Tanimoto Y, Shinagawa K, Tanimoto M
Volume
3
Pages
3
DOI
Peer Reviewed
-
