Development of a novel comprehensive therapy targeting aurora kinase-A for adult T cell leukemia

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591419
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Ehime University
• Principal Investigator: AZUMA Taichi 愛媛大学, 医学部附属病院, 講師 (10396252)
• Co-Investigator(Renkei-kenkyūsha): YASUKAWA Masaki 愛媛大学, 大学院医学系研究科, 教授 (60127917)
• Project Period (FY): 2011 – 2013
• Keywords: 造血器腫瘍 / 細胞免疫療法

Research Abstract

In this study, aiming at a development of novel adoptive immunotherapy against adult T-cell leukemia (ATL) which is one of the most treatment-refractory T-lymphoid malignancy, we newly demonstrated the clinical feasibility of adoptive immunotherapy targeting human telomerase reverse transcriptase (hTERT) for the treatment of ATL, and also demonstrated the potential advantage of Aurora kinase-A (AURKA) as a novel therapeutic target for ATL. In addition, we started to extend our therapeutic strategy against ATL from that based on T-cell receptor gene-modified T-cell to newly designed chimeric receptor gene-modified T cell-based one.

Research Products

• [Journal Article] Analysis of chemotherapy-induced neutropenia and optimal timing for prophylactic use of G-CSF in B-cell non-Hodgkin lymphoma patients treated with R-CHOP (2014)
  • Author(s): Shikata H, Yakushijin Y, Yamanouchi J, Azuma T, Yasukawa M
  • Journal Title: Int J Clin Oncol Volume: 19(1) Pages: 178-85
  • Peer Reviewed
• [Journal Article] Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia (2013)
  • Author(s): Miyazaki Y, Fujiwara H, Asai H, Ochi F, Ochi T, Azuma T, Ishida T, Okamoto S, Mineno J, Kuzushima K, Shiku H, Yasukawa M
  • Journal Title: Blood Volume: 121(24) Pages: 4894-901
  • Peer Reviewed
• [Journal Article] Role of activation-induced cytidine deaminase in the progression of follicular lymphoma (2012)
  • Author(s): Shikata H, Yakushijin Y, Matsushita N, Sakai A, Sugita A, Nakamura N, Yamanouchi J, Azuma T, Hato T,Yasukawa M
  • Journal Title: Cancer Sci Volume: 103(3) Pages: 415-21
  • Peer Reviewed
• [Presentation] Co-Administration of Gene-Modified CD4^+ T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia (2013)
  • Author(s): Fujiwara H, Azuma T, Yasukawa M, et al
  • Organizer: 55^<th> American Society of Hematology, Annual meeting and Exposition
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2013-12-08
• [Presentation] Human telomerase reverse transcriptase‒specific T-cell receptor gene transfer redirects T cells to display an effective antitumor reactivity against adult T-cell leukemia (2013)
  • Author(s): Fujiwara H, Azuma T, Yasukawa M, et al
  • Organizer: 39^<th> Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: London, UK
  • Year and Date: 2013-04-08
• [Book] 「多発性骨髄腫」高齢者総合診療ノート (2014)
  • Author(s): 東太地、安川正貴
  • Total Pages: 375-381
  • Publisher: 日本医事新報社
• [Book] 「組織球・樹状細胞の異常と血球貪食症候群」カラーテキスト血液病学(第2版) (2012)
  • Author(s): 東太地、安川正貴
  • Total Pages: 590-595
  • Publisher: 中外医学社
• [Remarks]
  • URL: http://www.m.ehime-u.ac.jp/school/int.med1/