Hematopoietic Stem Cell Transplantation

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591423
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Osaka City University
• Principal Investigator: HINO Masayuki 大阪市立大学, 医学(系)研究科(研究院), 教授 (50244637)
• Co-Investigator(Kenkyū-buntansha): NAKAMAE Hirohisa 大阪市立大学, 大学院医学研究科, 准教授 (30364003)
• Project Period (FY): 2011 – 2013
• Keywords: 同種造血幹細胞移植 / HLA半合致移植 / GVHD / 移植後シクロホスファミド / バイオマーカー / 消化管GVHD / ステロイド動注 / ベクロメタゾン

Research Abstract

A myeloablative regimen involved high-dose TBI impaired cardiac function. A high s-ferritin level before HCT might be associated with the development of LVH in the chronic phase of HCT. A high s-ferritin level after HCT might be a prognostic factor. Eosinophilia after allo-HCT was associated with better OS and a lower relapse rate. Dysregulated balance between Th1 and Th2 cytokines might play an important role in the incidence of HPS after allo-HCT. Prospective pilot study of HLA haplo-identical allogeneic PBSCT using cyclophosphamide post-transplantation for patients with a poor-prognosis or refractory leukemia and MDS showed that except for one patient who died due to disease progression, full donor T-cell chimerism was achieved at day 30 in all patients, 53% of patients developed grade II-III acute GVHD, the cumulative incidence of TRM at one year was 13%, and the OS at one year of all patients, patients in remission and those with active disease were 43%, 75% and 31%, respectively.

Research Products

• [Journal Article] PBSC collection from family donors in Japan : a prospective survey (2014)
  • Author(s): Kodera Y, Yamamoto K, Harada M, Morishima Y, Dohy H, Asano S, Ikeda Y, Nakahata T, Imamura M, Kawa K, Kato S, Tanimoto M, Kanda Y, Tanosaki R, Shiobara S, Kim SW, Nagafuji K, Hino M, Miyamura K, Suzuki R, Hamajima N, Fukushima M, Tamakoshi A
  • Journal Title: Bone Marrow Transplant Volume: 49 Pages: 195-200
  • DOI: 10.1038/bmt.2013.147
  • Peer Reviewed
• [Journal Article] Maintenance of complete remission after allogeneic stem cell transplantation in leukemia patients treated with Wilms tumor 1 peptide vaccine (2013)
  • Author(s): Maeda T, Hosen N, Fukushima K, Tsuboi A, Morimoto S, Matsui T, Sata H, Fujita J, Hasegawa K, Nishida S, Nakata J, Nakae Y, Takashima S, Nakajima H, Fujiki F, Tatsumi N, Kondo T, Hino M, Oji Y, Oka Y, Kanakura Y, Kumanogoh A, Sugiyama H
  • Journal Title: Blood Cancer J Volume: 3 Pages: e130
  • DOI: 10.1038/bcj.2013.29
  • Peer Reviewed
• [Journal Article] Prognostic factors and outcomes of unrelated bone marrow transplantation for Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) pre-treated with tyrosine kinase inhibitors (2013)
  • Author(s): Yoshimura T, Nakane T, Hirose A, Koh H, Nakamae M, Aimoto M, Nishimoto M, Hayashi Y, Terada Y, Nakamae H, Hino M
  • Journal Title: Osaka City Med J Volume: 59 Pages: 9-21
  • Peer Reviewed
• [Journal Article] Clinical factors predicting the response of acute graft-versus-host disease to corticosteroid therapy : an analysis from the GVHD Working Group of the Japan Society for Hematopoietic Cell Transplantation (2013)
  • Author(s): Murata M, Nakasone H, Kanda J, Nakane T, Furukawa T, Fukuda T, Mori T, Taniguchi S, Eto T, Ohashi K, Hino M, Inoue M, Ogawa H, Atsuta Y, Nagamura-Inoue T, Yabe H, Morishima Y, Sakamaki H, Suzuki R
  • Journal Title: Biol Blood Marrow Transplant Volume: 19 Pages: 1183-1189
  • DOI: 10.1016/j.bbmt.2013.05.003
  • Peer Reviewed
• [Journal Article] Use of per rectal portal scintigraphy to detect portal hypertension in sinusoidal obstructive syndrome following unrelated cord blood transplantation (2013)
  • Author(s): Okamura H, Hayashi Y, Nakamae H, Shiomi S, Nishimoto M, Koh H, Nakane T, Hino M
  • Journal Title: Acta Haematol Volume: 130 Pages: 83-86
  • DOI: 10.1159/000346438
  • Peer Reviewed
• [Journal Article] Risk factors affecting cardiac left-ventricular hypertrophy and systolic and diastolic function in the chronic phase of allogeneic hematopoietic cell transplantation (2013)
  • Author(s): Nishimoto M, Nakamae H, Koh H, Nakane T, Nakamae M, Hirose A, Hagihara K, Nakao Y, Terada Y, Ohsawa M, Hino M
  • Journal Title: Bone Marrow Transplant Volume: 48 Pages: 581-586
  • DOI: 10.1038/bmt.2012.179
  • Peer Reviewed
• [Journal Article] Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology (2013)
  • Author(s): Kim SW, Yoon SS, Suzuki R, Matsuno Y, Yi HG, Yoshida T, Imamura M, Wake A, Miura K, Hino M, Ishikawa T, Kim JS, Maeda Y, Lee JJ, Kang HJ, Lee HS, Lee JH, Izutsu K, Fukuda T, Kim CW, Yoshino T, Ohshima K, Nakamura S, Nagafuji K, Suzumiya J, Harada M, Kim CS
  • Journal Title: Leukemia Volume: 27 Pages: 1394-1397
  • DOI: 10.1038/leu.2012.321
  • Peer Reviewed
• [Journal Article] Eosinophilia, regardless of degree, is related to better outcomes after allogeneic hematopoietic stem cell transplantation (2012)
  • Author(s): Nakane T, Nakamae H, Hirose A, Nakamae M, Koh H, Hayashi Y, Nishimoto M, Umemoto Y, Yoshimura T, Bingo M, Okamura H, Yoshida M, Ichihara H, Aimoto M, Terada Y, Nakao Y, Ohsawa M, Hino M
  • Journal Title: Intern Med Volume: 51 Pages: 851-858
  • Peer Reviewed
• [Journal Article] Serum cytokine profiles in hemophagocytic syndrome following allogeneic hematopoietic stem cell transplantation (2012)
  • Author(s): Koh H, Nakane T, Sakamoto E, Katayama T, Nakamae H, Ohsawa M, Hino M
  • Journal Title: Acta Haemato Volume: 127 Pages: 182-185
  • DOI: 10.1159/000335536
  • Peer Reviewed
• [Journal Article] 非血縁者間末梢血幹細胞採取 (2012)
  • Author(s): 日野雅之
  • Journal Title: 日本アフェレーシス学会雑誌 Pages: 209-215
• [Journal Article] Immunoglobulin prophylaxis against cytomegalovirus infection in patients at high risk of infection following allogeneic hematopoietic cell transplantation (2011)
  • Author(s): Ichihara H, Nakamae H, Hirose A, Nakane T, Koh H, Hayashi Y, Nishimoto M, Nakamae M, Yoshida M, Bingo M, Okamura H, Aimoto M, Manabe M, Hagihara K, Terada Y, Nakao Y, Hino M
  • Journal Title: Transplant Proc Volume: 43 Pages: 3927-3932
  • DOI: 10.1016/j.transproceed.2011.08.104
  • Peer Reviewed
• [Journal Article] Feasibility of umbilical cord blood transplantation with a myeloablative, reduced toxicity-conditioning regimen
  • Author(s): Nishimoto M, Nakamae H, Nakamae M, Hirose A, Hagihara K, Koh H, Nakane T, Terada Y, Hino M
  • Journal Title: Bone Marrow Transplant Volume: (in press)
  • DOI: 10.1038/bmt.2014.60
  • Peer Reviewed
• [Presentation] Promising outcomes from intra-arterial steroid infusions in patients with treatment-resistant acute gastrointestinal graft-versus-host disease (2014)
  • Author(s): Nishimoto M, Koh H, Nakamae H, Hirose A, Nakamae M, Nakane T, Hayashi Y, Okamura H, Yoshimura Y, Koh S, Nanno S, Hamamoto S, Yamamoto A, Sakai Y, Nishida N, Matsuoka T, Miki Y, Hino M
  • Organizer: 40th Annual Meeting of the European Society for Blood and Marrow Transplantation
  • Place of Presentation: Milan, Italy
  • Year and Date: 20140320-0402
• [Presentation] 予後不良、治療抵抗性急性白血病、MDSに対する移植後CY大量療法によるHLA半合致末梢血幹細胞移植の単施設前向きpilot研究 (2014)
  • Author(s): 中前博久、康秀男、西本光孝、中嶋康博、南野智、吉村卓朗、康史朗、岡村浩史、幕内陽介、久野雅智、中根孝彦、中前美佳、廣瀬朝生、日野雅之
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄、沖縄コンベンションセンター
  • Year and Date: 20140307-09
• [Presentation] 患者とドナーのKIR遺伝子型が移植後CY大量療法を用いたハプロ移植後の再発に及ぼす影響 (2014)
  • Author(s): 康秀男、中前博久、幕内陽介、久野雅智、長崎譲慈、康史朗、岡村浩史、吉村卓朗、南野智、西本光孝、井上有希子、廣瀬朝生、中前美佳、中嶋康博、萩原潔通、寺田芳樹、中根孝彦、日野雅之
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄、沖縄コンベンションセンター
  • Year and Date: 20140307-09
• [Presentation] HLA一致血縁または7-8/8HLA一致非血縁ドナーからの同種造血幹細胞移植におけるMMFおよびカルシニューリン阻害剤を用いたGVHD予防の有用性:多施設共同第2相臨床試験 (2014)
  • Author(s): 中根孝彦、中前博久、黒澤彩子、岡村篤夫、日高道弘、山下卓也、河野彰夫、斉藤健、青山泰孝、畑中一生、片山義雄、薬師神公和、松井利充、高見昭良、山口拓洋、日野雅之、福田隆浩
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄、沖縄コンベンションセンター
  • Year and Date: 20140307-09
• [Presentation] Voriconazole vs. itraconazole for antifungal prophylaxis in patients with GVHD : A prospective randomized trial (2014)
  • Author(s): Hayashi Y, Kanda Y, Nakamae H, Kanamori H, Ohashi K, Hidaka M, Yano S, Hatanaka K, Kono A, Moriuchi Y, Ago H, Yamashita T, Takata T, Yoshida M, Hino M, Yamaguchi T, Fukuda T
  • Organizer: BMT tandem meeting
  • Place of Presentation: Dallas, Texas,USA
  • Year and Date: 20140226-0302
• [Presentation] HLA Haplo-Identical Peripheral Blood Stem Cell Transplantation Using High-Dose Cyclophosphamide Post-Transplantation For Poor Prognosis Or Refractory Acute Leukemia and Myelodysplastic Syndrome : A Prospective Pilot Study At a Single Center (2013)
  • Author(s): Nakamae H, Koh H, Nishimoto M, Nakashima Y, Nanno S, Yoshimura T, Koh S, Okamura H, Nagasaki J, Nakane T, Nakamae M, Hirose A, Hino M
  • Organizer: 55th American Society of Hematology
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20131207-10
• [Presentation] Gvhd Prophylaxis With Mycophenolate Mofetil and Calcineurin Inhibitor In Allogeneic Hematopoietic Cell Transplantation From HLA-Matched Siblings Or 7–8/8 HLA-Matched Unrelated Volunteer Donors : A Japanese, Multicenter, Phase II Trial (2013)
  • Author(s): Nakane T, Nakamae H, Kurosawa S, Okamura A, Hidaka M, Yamashita T, Kohno A, Saito T, Aoyama Y, Hatanaka K, Katayama Y, Yakushijin K, Matsui T, Takami A, Yamaguchi T, Hino M, Fukuda T
  • Organizer: 55th American Society of Hematology
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20131207-10
• [Presentation] Risk factor hor hemophagositic syndrome following allogeneic hematopoietic cell transplamtaion (2013)
  • Author(s): Nanno S, Koh H, Sakabe M, Nagasaki J, Okamura H, Koh S, Yoshimura T, Inaba A, Aimoto M, Nishimoto M, Hirose A, Nakamae M, Nakashima Y, Hagihara K, Nakao Y, Nakane T, Terada Y, Nakamae H, Hino M
  • Organizer: 第75回日本血液学会総会
  • Place of Presentation: ロイトン札幌, 札幌
  • Year and Date: 20131011-13
• [Presentation] Voriconazole vs itraconazole for antifungal prophylaxis in patients with GVHD : A randomized trial (2013)
  • Author(s): Hayashi Y, Kanda Y, Nakamae H, Kanamori H, Ohashi K, Hidaka M, Yano S, Hatanaka K, Kohno A, Moriuchi Y, Ago H, Yamashita T, Hino M, Yamaguchi T, Fukuda T
  • Organizer: 第75回日本血液学会
  • Place of Presentation: ロイトン札幌, 札幌
  • Year and Date: 20131011-13
• [Presentation] 東大医科研方式導入後のAraC/CY/TBIを前処置に用いた非血縁臍帯血移植成績の変化 (2013)
  • Author(s): 西本光孝、中前博久、廣瀬朝生、梅本由香里、中前美佳、康秀男、中根孝彦、日野雅之
  • Organizer: 第35回日本造血細胞移植学会
  • Place of Presentation: 石川県立音楽堂, 金沢
  • Year and Date: 20130307-09
• [Presentation] 当院におけるステロイド抵抗性・依存性急性GVHDに対する少量サイモグロブリン(ATG)治療成績 (2013)
  • Author(s): 西本光孝、中前博久、廣瀬朝生、梅本由香里、中前美佳、康秀男、中根孝彦、日野雅之
  • Organizer: 第35回日本造血細胞移植学会
  • Place of Presentation: 石川県立音楽堂, 金沢
  • Year and Date: 20130307-09
• [Presentation] 同種造血幹細胞移植後慢性期における心機能障害リスク因子の評価 (2012)
  • Author(s): 西本光孝、中前博久、中根孝彦、康秀男、林良樹、中前美佳、吉田全宏、備後真登、岡村浩史、相本瑞樹、間部賢寛、吉村卓朗、稲葉晃子、南野智、廣瀬朝生、萩原潔通、中尾吉孝、寺田芳樹、日野雅之
  • Organizer: 第34回日本造血細胞移植学会
  • Place of Presentation: 大阪国際会議場, 大阪
  • Year and Date: 20120224-25
• [Presentation] 同種造血幹細胞移植後好酸球増多およびその程度が移植予後へ与える影響についての検討 (2012)
  • Author(s): 中根孝彦、中前博久、廣瀬朝生、康秀男、中前美佳、林良樹、西本光孝、吉田全宏、備後真登、岡村浩史、梅本由香里、稲葉晃子、吉村卓朗、市原弘善、南野智、萩原潔通、寺田芳樹、日野雅之
  • Organizer: 第34回日本造血細胞移植学会
  • Place of Presentation: 大阪国際会議場, 大阪
  • Year and Date: 20120224-25
• [Presentation] 非血縁者末梢血幹細胞採取における施設内CTCとバンクコーディネーターの協働の試み (2012)
  • Author(s): 梅本由香里、中前美佳、廣瀬朝生、樋口智子、片山貴子、津田泉、中根孝彦、日野雅之
  • Organizer: 第34回日本造血細胞移植学会
  • Place of Presentation: 大阪国際会議場, 大阪
  • Year and Date: 20120224-25
• [Presentation] Risk Factors Affecting Cardiac Left Ventricular Systolic and Diastolic Function and Hypertrophy in the Chronic Phase Post-Allogeneic Hematopietic Cell Transplantation (2011)
  • Author(s): Nishimoto M, Nakamae H, Nakane T, Koh H, Hayashi Y, Nakamae M, Yoshida M, Bingo M, Okamura H, Aimoto M, Manabe M, Yoshimura T, Inaba A, Nanno S, Hirose A, Hagihara K, Nakao Y, Terada Y, Hino M
  • Organizer: 53th American Society of Hematology
  • Place of Presentation: San-Diego,USA
  • Year and Date: 20111210-13
• [Presentation] Serum cytokine profiles in hemophagocytic syndrome after allogeneic hematopoietic cell transplant (2011)
  • Author(s): Koh H、Koh KR、Nakane T、Sakamoto E、Katayama T、Nakamae M、Terada Y、Nakamae H、Yamane T、Hino M
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋国際会議場, 名古屋
  • Year and Date: 20111014-16
• [Book] 末梢血幹細胞採取.東條有伸編G-CSFの基礎と臨床 (2013)
  • Author(s): 日野雅之、中前博久、梅本由香里
  • Total Pages: 175-186
  • Publisher: 医薬ジャーナル社
• [Book] 自家・同種骨髄・末梢血幹細胞の採取方法、ドナーの安全管理神田善伸編、みんなに役立つ造血幹細胞移植の基礎と臨床(改訂版) (2012)
  • Author(s): 日野雅之、中前博久、中根孝彦、梅本由香里
  • Total Pages: 246-253
  • Publisher: 医薬ジャーナル社
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/labmed/