2013 Fiscal Year Final Research Report
IRF-4 is associated with the development of granulomas in autoimmune disease
| Project/Area Number |
23591442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YUI Katsuyuki 長崎大学, 医学部, 教授 (90274638)
HONMA Kiri 長崎大学, 医学部, 准教授 (70307940)
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| Project Period (FY) |
2011 – 2013
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| Keywords | IRF4 / IRF1 / 自己免疫 / 肉芽腫 |
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| Research Abstract |
Mechanisms of granuloma formation in autoimmune diseases is unknown. We found that transcription factor IRF4-deficient lupus-prone MRL/lpr mice develop granulomas with Langhans giant cells in multiple organs including lung. We also found that IRF4-deficient MRL/lpr mice had increased numbers of IFN-g-producing Th1 cells with elevated levels of serum IFN-g. While, transcription factor IRF1-deficient MRL/lpr mice had increased numbers of IL-4-producing Th2 cells and granulomas with foreign body giant cells in their lung. Our data indicate that transcription factor IRF4 and IRF1 play important roles to maintain Th1/Th2-cell/cytokine balance, and defect of these transcription factors causes development of granulomatous lesions in multiple organs.
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