2013 Fiscal Year Final Research Report
Adipokine network in systemic autoimmune diseases
| Project/Area Number |
23591449
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 膠原病 / アディポカイン / レジスチン / アディポネクチン / レプチン / ケメリン |
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| Research Abstract |
Adipokines are molecules produced by adipose tissue. We have found that adiponectin, an adipokine stimulates inflammation in rheumatoid synovial fibroblasts. In this study, we measured serum adipokine concentrations in patients with systemic connective tissue diseases. We also conducted in vitro studies by primary cultures of rheumatoid synovial fibroblasts or peripheral blood mononuclear leukocytes. Not only pro-hyperglycemic but also anti-hyperglycemic adipokines showed a pro-inflammatory property in the patients with systemic connective tissue diseases. Further investigations will be needed to clarify the roles of adipokine network in pathogenesis of systemic autoimmune diseases.
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[Journal Article] Efficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan2012
Author(s)
Imagawa T, Takei S, Umebayashi H, Yamaguchi K, Itoh Y, Kawai T, Iwata N, Murata T, Okafuji I, Miyoshi M, Onoe Y, Kawano Y, Kinjo N, Mori M, Mozaffarian N, Kupper H, Santra S, Patel G, Kawai S, Yokota S
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Journal Title
Clin Rheumatol
Volume: 31(12)
Pages: 1713-1721
DOI
Peer Reviewed
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