2013 Fiscal Year Final Research Report
Possible involvements of proton-sensing receptors in alleric airway inflammation and fibrosis
| Project/Area Number |
23591456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | University of Fukui (2012-2013)
Gunma University (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAJIMA Fumikazu 群馬大学, 生体調節研究所, 教授 (30142748)
HISADA Takeshi 群馬大学, 医学部, 講師 (10344938)
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| Project Period (FY) |
2011 – 2013
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| Keywords | プロトン / OGR1 / GPCR / 気道炎症 / 気管支喘息 / 樹状細胞 / 気管支平滑筋 |
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| Research Abstract |
Ovarian cancer G protein-coupled receptor 1 (OGR1) stimulation by extracellular protons causes the activation of G proteins and subsequent cellular functions. We showed that OGR1-deficient mice are resistant to the cardinal features of asthma, including airway eosinophilia, airway hyperresponsiveness, and goblet cell metaplasia in a murine allergic asthma model. On the other hand, acidic pH alone induced a substantial production of connective tissue growth factor (CTGF) and enhanced transforming growth factor-beta-induced CTGF mRNA and protein expression through OGR1 in human airway smooth muscle cells. Our results suggest that OGR1 plays an important role in the pathogenesis of allergic airway inflammtion and airway remodelling and OGR1 may be a therapeutic target of asthma.
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[Journal Article] Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model2013
Author(s)
Aoki H, Mogi C, Hisada T, Kamide Y, Ichimonji I, Tomura H, Tobo M, Sato K, Tsurumaki H, Dobashi K, Mori T, Harada H, Yamada M, Mori M, Ishizuka T, Okajima F
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Journal Title
PLoS ONE
Volume: 8(11)
Pages: e79985
DOI
Peer Reviewed
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[Journal Article] Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO2011
Author(s)
Ishizuka T, Matsuzaki S, Aoki H, Yatomi Y, Kamide Y, Hisada T, Tsuburai T, Dobashi K, Ohshima K, Akiyama K, Mori M
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Journal Title
Allergy Asthma Clin Immunol
Volume: 7
Pages: 15
DOI
Peer Reviewed
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[Journal Article] Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in airway smooth muscle cells2011
Author(s)
Matsuzaki S, Ishizuka T, Yamada H, Kamide Y, Hisada T, Ichimonji I, Aoki H, Yatomi Y, Komachi M, Tsurumaki H, Ono A, Koga Y, Dobashi K, Mogi C, Sato K, Tomura H, Mori M, Okajima F
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Journal Title
Biochem Biophys Res Commun
Volume: 413
Pages: 499-503
DOI
Peer Reviewed
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[Presentation] 喘息コントロール評価のためのGスケール問診票の有用性2013
Author(s)
石塚 全,久田剛志,上出庸介,青木悠,関 香織,小野昭浩,古賀康彦,土橋邦生,本定千知,住田泰之,安斎正樹,門脇麻衣子,森川美羽,梅田幸寛,飴嶋慎吾,石崎武志,草野元康,森 昌朋
Organizer
第25回日本アレルギー学会春季臨床大会
Place of Presentation
横浜市
Year and Date
2013-05-11
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[Presentation] 長期管理薬で治療中の気管支喘息患者における喘息症状,鼻・副鼻腔炎症状と胃食道逆流症状との関連2013
Author(s)
石塚 全,久田剛志,上出庸介,青木 悠,関 香織,西岡正樹,解良恭一,岩崎靖樹,小野昭浩,古賀康彦,砂長則明,土橋邦生,草野元康,森 昌朋
Organizer
第53回日本呼吸器学会学術講演会
Place of Presentation
東京
Year and Date
2013-04-21
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[Presentation] 喘息患者における胃食道逆流症状,鼻副鼻腔炎症状,喘息症状の相互関係2012
Author(s)
石塚 全,久田剛志,上出庸介,小野昭浩,古賀康彦,岩崎靖樹,砂長則明,青木 悠,関 香織,土橋邦生,森 昌朋
Organizer
第62回日本アレルギー学会秋季学術大会
Place of Presentation
大阪市
Year and Date
2012-12-01
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[Presentation] 難治性喘息患者におけるPulse LCAP療法の安全性と有効性に関する検討2012
Author(s)
石塚 全,久田剛志,上出庸介,青木 悠,松崎晋一,鶴巻寛朗,解良恭一,岩崎靖樹,宇津木光克,小野昭浩,古賀康彦,砂長則明,土橋邦生,森 昌朋
Organizer
第52回日本呼吸器学会学術講演会
Place of Presentation
神戸市
Year and Date
2012-04-20
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[Presentation] Efficacy of high-dose leukocytapheresis using extracorporeal circulation through a large leukocyte-removal filter column in patients with refractory asthma2011
Author(s)
Ishizuka T, Koike A, Hatori M, Matsuzaki S, Kamide Y, Aoki H, Hisada T, Tsurumaki H, Ono A, Koga Y, Dobashi K, Suzuki K, Mori M
Organizer
European Respiratory Society International Congress 2011
Place of Presentation
アムステルダム
Year and Date
2011-09-27
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[Presentation] ミニシンポジウム3 好酸球性肺炎など.嗅覚障害と篩骨洞病変を有する気管支喘息症例の臨床的検討2011
Author(s)
石塚 全,久田剛志,小野昭浩,古賀康彦,鶴巻寛朗,松崎晋一,関 香織,青木 悠,上出庸介,矢冨正清,森 宗昌,土橋邦生,森 昌朋
Organizer
第23回日本アレルギー学会春季臨床大会
Place of Presentation
千葉市
Year and Date
2011-05-14
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[Presentation] オフライン法による呼気NO濃度測定値を利用した喘息有症率調査2011
Author(s)
石塚 全,松崎晋一,青木 悠,矢冨正清,上出庸介,鶴巻寛朗,今井久雄,解良恭一,小野昭浩,古賀康彦,岩崎靖樹,砂長則明,久田剛志,土橋邦生,森 昌朋
Organizer
第51回日本呼吸器学会学術講演会
Place of Presentation
東京
Year and Date
2011-04-22
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