Analyses of novel NF-kB inhibitory signals

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591458
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Chiba University
• Principal Investigator: SUZUKI KOTARO 千葉大学, 医学部附属病院, 講師 (90554634)
• Co-Investigator(Renkei-kenkyūsha): NAKAJIMA Hiroshi 千葉大学, 大学院医学研究院, 教授 (00322024)
• Project Period (FY): 2011 – 2013
• Keywords: サイトカイン

Research Abstract

The regulatory mechanisms, which could be applicable for the treatment of allergic contact dermatitis, are still largely unknown. To determine roles of B and T lymphocyte attenuator (BTLA) in hapten-induced contact hypersensitivity (CHS), BTLA KO mice and wild-type (WT) mice were subjected to dinitrofluorobenzene (DNFB)-induced CHS. BTLA KO mice showed enhanced CHS as compared to WT mice. To evaluate the therapeutic potential of an agonistic agent for BTLA on CHS, the effects of an agonistic anti-BTLA antibody (6A6) on CHS were examined. In vivo injection of 6A6 suppressed CHS. Taken together, these results suggest that stimulation of BTLA with agonistic agents has therapeutic potential in CHS.

Research Products

• [Journal Article] Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells (2013)
  • Author(s): Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, Minamino T, Hirose K, Nakajima H
  • Journal Title: J Immunol Volume: 191(7) Pages: 3614-23
  • DOI: 10.4049/jimmunol.1300509
  • Peer Reviewed
• [Journal Article] Alteration of circulating miRNAs in SSc : miR-30b regulates the expression of PDGF receptorβ (2013)
  • Author(s): Tanaka S, Suto A, Ikeda K, Sanayama Y, Nakagomi D, Iwamoto T, Suzuki K, Kambe N, Matsue H, Matsumura R, Kashiwakuma D, Iwamoto I, Nakajima H
  • Journal Title: Rheumatology (Oxford) Volume: 52(11) Pages: 1963-72
  • DOI: 10.1093/rheumatology/ket254
  • Peer Reviewed
• [Journal Article] Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells (2013)
  • Author(s): Hosokawa J, Suzuki K, Nakagomi D, Tamachi T, Takatori H, Suto A, Nakajima H
  • Journal Title: Int Arch Allergy Immunol Volume: 161 Suppl 2 Pages: 37-43
  • DOI: 10.1159/000350357
  • Peer Reviewed
• [Journal Article] [18F]FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis (2013)
  • Author(s): Tanaka S, Ikeda K, Uchiyama K, Iwamoto T, Sanayama Y, Okubo A, Nakagomi D, Takahashi K, Yokota M, Suto A, Suzuki K, Nakajima H
  • Journal Title: Rheumatology (Oxford) Volume: 52(7) Pages: 1271-8
  • DOI: 10.1093/rheumatology/ket112
  • Peer Reviewed
• [Journal Article] B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells (2013)
  • Author(s): Kobayashi Y, Iwata A, Suzuki K, Suto A, Kawashima S, Saito Y, Owada T, Kobayashi M, Watanabe N, Nakajima H
  • Journal Title: Proc Natl Acad Sci U S A Volume: 110(13) Pages: 890-8
  • DOI: 10.1002/art.37848
  • Peer Reviewed
• [Journal Article] Ultrasound can improve the accuracy of the 2010 American College of Rheumatology/European League against rheumatism classification criteria for rheumatoid arthritis to predict the requirement for methotrexate treatment (2013)
  • Author(s): Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K, Yamagata M, Takatori H, Suzuki K, Takabayashi K, Nakajima H
  • Journal Title: Arthritis Rheum Volume: 65(4) Pages: 890-8
  • DOI: 10.1002/art.37848
  • Peer Reviewed
• [Journal Article] Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity (2013)
  • Author(s): Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H
  • Journal Title: J Invest Dermatol Volume: 133(3) Pages: 702-11
  • DOI: 10.1038/jid.2012.396
  • Peer Reviewed
• [Journal Article] Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation (2012)
  • Author(s): Tsutsuki H, Yahiro K, Suzuki K, Suto A, Ogura K, Nagasawa S, Ihara H, Shimizu T, Nakajima H, Moss J, Noda M
  • Journal Title: Infect Immun Volume: 80(11) Pages: 3939-51
  • DOI: 10.1128/IAI.00581-12
  • Peer Reviewed
• [Journal Article] Critical roles of IĸB kinase subunits in mast cell degranulation (2012)
  • Author(s): Nakagomi D, Suzuki K, Nakajima H
  • Journal Title: Int Arch Allergy Immunol Volume: Suppl 1 Pages: 92-5
  • DOI: 10.1159/000337800
  • Peer Reviewed
• [Presentation] Tumor suppressos p53 inhibits systemic autoimmune diseases by inducing regulatory T cells (2013)
  • Author(s): 川島広稔、高取宏昌、鈴木浩太郎、岩田有史、横田雅也、須藤明、南野徹、廣瀬晃一、中島裕史
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張、千葉
  • Year and Date: 2013-12-13
• [Presentation] SOCS3 expressed in macrophages inhibits contact hypersensitivity by suppressing MMP-12 production (2013)
  • Author(s): 中込大樹、鈴木浩太郎、中島裕史
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張、千葉
  • Year and Date: 2013-12-13
• [Presentation] 接触過敏症におけるマスト細胞産生性IFN-gの役割 (2013)
  • Author(s): 中込大樹、鈴木浩太郎、中島裕史
  • Organizer: 第63回日本アレルギー学会秋期学術大会
  • Place of Presentation: 四谷、東京
  • Year and Date: 2013-11-29
• [Presentation] 中枢神経ループス患者における脳脊髄液中BAFF値の検討 (2012)
  • Author(s): 細川淳一、鈴木浩太郎、中込大樹、岩本太郎、池田啓、中島裕史
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: 品川、東京
  • Year and Date: 2012-04-27
• [Remarks]
  • URL: http://www.m.chiba-u.jp/class/allergy/