2012 Fiscal Year Final Research Report
Clarification of the functional roles of matrix proteins in the pathogenesis of allergic inflammation
| Project/Area Number |
23591465
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARIMA Kazuhiko 佐賀大学, 医学部, 講師 (60336112)
SUZUKI Shoichi 佐賀大学, 医学部, 助教 (40253695)
SHIRAISHI Hiroshi 佐賀大学, 医学部, 助教 (80452837)
OHTA Shoichiro 佐賀大学, 医学部, 助教 (20346886)
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| Project Period (FY) |
2011 – 2012
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| Keywords | アレルギー / ぜんそく / トランスレーショナルリサーチ / 免疫学 / 生体分子 |
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| Research Abstract |
It is well known that type 2 immunity is important for allergicinflammation. To examine how IL-4 or IL-13, signature type 2 cytokines, contributes to the pathogenesis of allergic inflammation, we in this study analyzed functions of periostin,an extracellular matrix protein induced by IL-4 or IL-13. We found that periostin playsan important role for the chronicity of allergic inflammation in atopic dermatitis. IL-4 or IL-13 induces periostin production in fibroblasts. Periostin induces TSLP production in keratinocytes by binding to integrin molecules on their cell surface. Then TSLP induces Th2 differentiation in naive T cells. Thus, the vicious cycle composed of IL-4/IL-13, periostin, integrin, and TSLP is important for the pathogenesisof atopic dermatitis. The finding that the neutralizing antibodies against av integrin inhibited dermatitis suggests that periostin can be a therapeutic target against atopic dermatitis. We also found that periostin is involved in the pathogenesis of variousinflammatory diseases such as pulmonary fibrosis, scleroderma, gallbladder carcinoma,IgG4-related sclerosing sialadenitis, eosinophilic otitis media, allergic rhinitis and chronic rhinosinusitis, and proliferative diabetic retinopathy. Furthermore, we found that periostin plays an important role in wound repair, which is a physiological function of periostin. The underlying mechanism of the chronicity of allergic inflammationby periostin is the first example showing some host factor is involved in it. It is hopedthat development of inhibitors targeting periostin will lead to development of therapeutic agents against atopic dermatitis having a novel mechanism.
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Research Products
(54 results)
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[Journal Article] Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis2012
Author(s)
Uchida M, Shiraishi H, Ohta S, Arima K, Taniguchi K, Suzuki S, Okamoto M, Ahlfeld SK, Ohshima K, Kato S, Toda S, Sagara H Aizawa H, Hoshino T, Conway SJ, Hayashi S, Izuhara K
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Journal Title
Am J Respir Cell Mol Biol
Volume: vol.46
Pages: 677-686
DOI
Peer Reviewed
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[Journal Article] Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts2012
Author(s)
Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway SJ, Narisawa Y, Katayama I, Izuhara K, Naka T
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Journal Title
Exp Dermatol
Volume: vol.21
Pages: 331-336
DOI
Peer Reviewed
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[Journal Article] Periostin promotes chronic allergic inflammation in response to Th2 cytokines2012
Author(s)
Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, Toda S, Inagaki N, Kurihara Y, Hayashida S, Takeuchi S, Koike K, Ono J, Noshiro H, Furue M, Conway SJ, Narisawa Y, Izuhara K
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Journal Title
J Clin Invest
Volume: vol.122
Pages: 2590-2600
DOI
Peer Reviewed
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[Journal Article] Periostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytes2012
Author(s)
Shiraishi H, Masuoka M, Ohta S, Suzuki S, Arima K, Taniguchi K, Aoki S, Toda S, Yoshimoto T, Inagaki N, Conway SJ, Narisawa Y, Izuhara K
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Journal Title
Allergology Int
Volume: vol.61
Pages: 563-572
DOI
Peer Reviewed
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[Journal Article] Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma2011
Author(s)
Fujimoto K, Kawaguchi T, Nakashima O, Ono J, Ohta S, Kawaguchi A, Tonan T, Ohshima K, Yano H, Hayabuchi N, Izuhara K, Sata M
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Journal Title
Oncol Rep
Volume: vol.25
Pages: 1211-1216
DOI
Peer Reviewed
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[Journal Article] Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias2011
Author(s)
Okamoto M, Hoshino T, Kitasato Y, Sakazaki Y, Kawayama T, Fujimoto K, Ohshima K, Shiraishi H, Uchida M, Ono J, Ohta S, Kato S, Izuhara K, Aizawa H
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Journal Title
Eur Respir J
Volume: vol.37
Pages: 1119-1127
DOI
Peer Reviewed
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[Journal Article] Increased expression of periostin in vitreous and fibrovascular membranes obtained from patients with proliferative diabetic retinopathy2011
Author(s)
Yoshida S, Ishikawa K, Asato R, Arima M, Sassa Y, Yoshida A, Yoshikawa H, Narukawa K, Obika S, Ono J, Ohta S, Izuhara K, Kono T, Ishibashi T
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Journal Title
Invest Ophthalmol Vis Sci
Volume: vol.52
Pages: 5670-5678
DOI
Peer Reviewed
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[Journal Article] Efficacy of omalizumab in eosinophilic chronic rhinosinusitis patients with asthma
Author(s)
Tajiri T, Matsumoto H, Hiraumi H, Ikeda H, Morita K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Ito J, Niimi A, Mishima M
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Journal Title
Peer Reviewed
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