2013 Fiscal Year Final Research Report
Analysis of the role transcription factors, especially c-Maf, play in the differentiation and functions of T helper cells
| Project/Area Number |
23591467
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saitama Medical University |
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Principal Investigator |
SATO Kojiro 埼玉医科大学, 医学部, 講師 (10372434)
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| Project Period (FY) |
2011 – 2013
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| Keywords | c-Maf / メモリー / Th細胞 / リンパ球 / IL-17 / Th17 |
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| Research Abstract |
In the analysis of T-cell specific c-Maf transgenic (Tg) mice, we observed that Tg Th cells have effector/memory phenotypes. When effector/memory Th cells were induced by transferring WT Th cells into Rag2 deficient mice, these cells also expressed c-Maf at high level. Based on these observations, we performed transcriptome analysis of c-Maf deficient Th cells. We also analyzed human naive/central memory/effector memory Th cells derived from peripheral blood and confirmed that the expression of MAF was also increased significantly in human memory Th cells.
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Author(s)
Asanuma YF, Shimada Y, Kouzu N, Yokota K, Nakajima K, Sato K, Akiyama Y, Isozaki M, Mikami AS, Kobayashi H, Mimura T
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Journal Title
Mod Rheumatol
Volume: 23(2)
Pages: 269-75
DOI
Peer Reviewed
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Author(s)
Kanemaru K, Nakamura Y, Sato K, Kojima R, Takahashi S, Yamaguchi M, Ichinohe M, Kiyonari H, Shioi G, Kabashima K, Nakahigashi K, Asagiri M, Jamora C, Yamaguchi H, Fukami K
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Journal Title
Nat Commun
Volume: 3
Pages: 963
DOI
Peer Reviewed
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