2013 Fiscal Year Final Research Report
Investigation of mechanisms of human mast cell activation by respiratory syncytial virus (RSV) and human rhinovirus (HRV) and involvement of asthma inception by these viruses
| Project/Area Number |
23591470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Hirokazu 国立感染研究所, 感染症情報センター, 室長 (20391807)
YOSHIHARA Shigemi 独協医科大学, 医学部, 准教授 (80220713)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ヒトマスト細胞 / RSウイルス / ヒトライノウイルス / 気管支喘息 / 喘息 / トリプターゼ / 鼻汁 / 喀痰 |
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| Research Abstract |
Although asthma inception is associated with infection with respiratory syncytial virus (RSV) and/or human rhinovirus (HRV), the mechanisms remains unclear. Since we found elevated concentration of mast cell tryptase in nasal discharges/sputa from children under 3 years, who had RSV-induced bronchiolitis with wheezing in the first time in their lives, we hypothesized that these viruses might directly activate human mast cells to induce degranulation. In our in vitro studies, these viruses did not directly activate human mast cells to induce degranulation. Concentrations of RANTES and TGF-beta in nasal secretions/sputa, which were taken at the first time wheezing in their lives from children with no family history of asthma were significantly higher in children who have had wheezing repeatedly than those who have had no repeated wheezing.
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Research Products
(16 results)
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[Journal Article] Expression of MrgX2 on mast cells is upregulated in skin of severe chronic urticaria2014
Author(s)
Fujisawa D, Kashiwakura J, Kita H, Kikukawa Y, Fujitani Y, Sasaki-Sakamoto T, Kuroda K, Nunomura S, Hayama K, Terui T, Ra C, Okayama Y
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Journal Title
J Allergy Clin Immunol
Volume: (In press)
Peer Reviewed
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[Journal Article] Cytokine profiles, signaling pathways, and effects of fluticasone propionate in respiratory syncytial virus-infected human fetal lung fibroblasts2013
Author(s)
Seki E, Yoshizumi M, Tanaka R, Ryo A, Ishioka T, Tsukagoshi H, Kozawa K, Okayama Y, Okabe-Kado J, Goya T, Kimura H
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Journal Title
Cell Biology International
DOI
Peer Reviewed
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[Journal Article] Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through FcγRI and FcγRII2013
Author(s)
Lee H, Kashiwakura J, Matsuda A, Watanabe Y, Sakamoto-Sasaki T, Matsumoto K, Hashimoto N, Saito S, Ohmori K, Nagaoka M, Tokuhashi Y, Ra C, Okayama Y
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Journal Title
Arthritis Rheum
Volume: 65 (1)
Pages: 109-119
Peer Reviewed
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[Journal Article] The interaction between Lyn and FcεRIβis indispensable for FcεRI-mediated human mast cell activation2012
Author(s)
Okayama Y, Kashiwakura J, Matsuda A, Sasaki-Sakamoto T, Nunomura S, Yokoi N, Ebihara N, Kuroda K, Ohmori K, Saito H, Ra C
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Journal Title
Allergy
Volume: 67(10)
Pages: 1241-1249
Peer Reviewed
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[Journal Article] A molecular epidemiological study of respiratory viruses detected in Japanese children with acute wheezing illness2011
Author(s)
Fujitsuka A, Tsukagoshi H, Arakawa M, Goto-Sugai K, Ryo A, Okayama Y, Mizuta K, Nishina A, Yoshizumi M, Kaburagi Y, Noda M, Tashiro M, Okabe N, Mori M, Yokota S, Kimura H
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Journal Title
BMC Infectious Diseases
Volume: 11
Pages: 168-78
Peer Reviewed
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[Presentation] 呼吸器ウイルス,特に喘息関連ウイルスの基礎,分子疫学および感染細胞のサイトカイン産生,教育講演72011
Author(s)
木村博一,塚越博之,野田雅博,岡山吉道,菅井和子,小澤邦壽,梁明秀,田代眞人,水田克己,岡部信彦
Organizer
第61回日本アレルギー学会秋季学術大会
Place of Presentation
東京
Year and Date
2011-11-11
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