2013 Fiscal Year Final Research Report
Antimicrobial chemotherapy for biofilm-related infection caused by multidrug-resistant pathogen
| Project/Area Number |
23591472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tohoku Pharmaceutical University (2012-2013)
Tohoku University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | ﾊﾞｲｵﾌｨﾙﾑ / ﾏｸﾛﾗｲﾄﾞ / ｸﾗﾘｽﾛﾏｲｼﾝ / ダプトマイシン / S.aureus |
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| Research Abstract |
It is known that bacteria which attached to the implants such as the artificial joints of the orthopedics field or the prosthetic valves of the cardiovascular surgery form biofilms. In this case, because an antibacterial agent is hard to arrive at the bacteria in the biofilms, an infectious disease is intractable. In this study, it was found that the clarithromycin of macrolide removed around 50% of biofilms formed by Staphylococcus aureus. Therefore the biofilm formed contamination model on the implant by MRSA which became the problem for nosocomial infection was made.
It was confirmed that biofilm formed S. aureus strains were sterilized 72 hours later by combination of clarithromycin and daptomycin treatment.
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