2013 Fiscal Year Final Research Report

Research for novel antimicrobial agents specifically targeting defence system of multi-drug resistant bacteria against oxidative stress.

Research Project

Project/Area Number	23591476
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Infectious disease medicine
Research Institution	The University of Tokushima
Principal Investigator	SHIBATA Hirofumi 徳島大学, ヘルスバイオサイエンス研究部, 助教 (00093865)
Project Period (FY)	2011 – 2013
Keywords	新規抗菌薬 / 多剤耐性菌 / 感染症
Research Abstract	An appropriate antibiotic plays a crucial role in treatment of infectious diseases caused by pathogenic microorganisms. At present, antibiotics still work well for most patients. But, for some patients, their diseases have become difficult to treat because of antibiotic resistance, and they urgently need new antibiotic treatment options. In the present research, using a screening system that specifically target a defence mechanism whereby bacterial cells escape from lethal damage caused by reactive oxygene species, some iron chelators were found to be lead compounds as a potential drug target for treatment against multi-drug resistant bacteria.