2013 Fiscal Year Final Research Report
Role of S100A8/S100A9 in Human Herpesvirus 6 Replication
| Project/Area Number |
23591486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
HAYASHI Shuhei (鄒 平) 兵庫医科大学, 医学部, 講師 (40322185)
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| Co-Investigator(Kenkyū-buntansha) |
OKUNO Toshiomi 兵庫医科大学, 医学部, 教授 (10221152)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ヒトヘルペスウイルス６（HHV-6） / S100A8 / S100A9 / ウイルス増殖 |
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| Research Abstract |
Human herpesvirus 6 (HHV-6) replicates predominantly in CD4-positive lymphocytes in vivo and in vitro and may establish latent infection in the monocyte/macrophage-lineage cells. It has been proved that HHV-6B is the etiologic agent of exanthem subitum, whereas HHV-6A has not yet been associated with any human diseases. Here, we showed that HHV-6 induced the expression of S100A8 and S100A9 in HHV-6 infected CD4+ T cells. Furthermore, we found that S100A9 interacted with HHV-6B U83. S100A9 significantly enhanced the HHV-6 replication. These findings suggest the S100A8/S100A9 may have an important role in the HHV-6 replication and pathogenesis.
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[Journal Article] Evaluation of VZV-Specific Cell-Mediated Immunity in Adults Infected With HIV-1 by Using a Simple IFN-γRelease Assay2013
Author(s)
Watanabe D, Otani N, Suzuki S, Dohi H, Hirota K, Yonemoto H, Koizumi Y, Otera H, Yajima K, Nishida Y, Uehira T, Shima M, Shirasaka T, Okuno T
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Journal Title
J Med Virol
Volume: 85
Pages: 1313-1320
DOI
Peer Reviewed
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