2013 Fiscal Year Final Research Report
Neurological mechanism for auditory hypersensitivity in autism spectrum disorder: MEG study
| Project/Area Number |
23591494
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SHIMONO KURIKO 大阪大学, その他の研究科, 講師 (60403185)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKINAGA Takeshi 大阪大学, 医学系研究科, 講師 (30362734)
HIRATA Masayuki 大阪大学, 医学系研究科, 準教授 (30372626)
TANIIKE Masako 大阪大学, 連合小児発達学研究科, 教授 (30263289)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 脳磁図 / 自閉症スペクトラム障害 / 聴覚過敏性 |
|---|
| Research Abstract |
To investigate the neurological mechanism of the auditory hypersensitivity in autism spectrum disorder, we measured auditory-evoked field values (M50, M100) to tone pip stimuli using magnetoencephalography (MEG), and analyzed their association with severity of hypersensitivity. In ASD with hypersensitivity group, the latency for M50 and M100 were prolonged, increased response power and correlated with severity of hypersensitivity. Furthermore, M50 responses were progressively increased to repeated sounds, and response duration was prolonged in ASD with hypersensitivity.
Those results were suggested that auditory hypersensitivity in ASD could be related with abnormality of sensory gating system in thalamus and /or reduction of cortical inhibitory system.
|
-
-
-
[Journal Article] Prognostic factors for acute encephalopathy with bright tree appearance2014
Author(s)
Azuma J, Nabatame S, Nakano S, Iwatani Y, Kitai Y, Tominaga K, Kagitani-Shimono K, Okinaga T, Yamamoto T, Nagai T, Ozono K
-
Journal Title
-
[Journal Article] A case of cerebral hypomyelination with spondylo-epi-metaphyseal dysplasia2013
Author(s)
Kimura-Ohba S, Kagitani-Shimono K, Hashimoto N, Nabatame S, Okinaga T, Murakami A, Miyake, Matsumoto N, Osaka H, Hojo K, Tomita R, Taniike M, Ozono K
-
Journal Title
Am J Med Genet
Volume: 161A(1)
Pages: 203-7
-
-
[Journal Article] Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders2013
Author(s)
Tachibana M, Kagitani-Shimono K, Mohri I, Yamamoto T, Sanefuji W, Nakamura A, Oishi M, Kimura T, Onaka T, Ozono K, Taniike M
-
Journal Title
J Child Adolesc Psychopharmacol
Volume: 23(2)
Pages: 123-7
-
[Journal Article] Which is the most appropriate disconnection surgery for refractory epilepsy in childhood?2013
Author(s)
Kishima H, Oshino S, Tani N, Maruo Y, Morris S, Ming Khoo H, Yanagisawa T, Shimono K, Okinaga T, Hirata M, Kato A, Yoshimine T
-
Journal Title
Neurol Med Chir(Tokyo)
Volume: 53(11)
Pages: 814-20
-
-
[Journal Article] Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity2012
Author(s)
Matsuzaki J, Kagitani-Shimono K, Goto T, Sanefuji W, Yamamoto T, Sakai S, Uchida H, Hirata M, Mohri I, Yorifuji S, Taniike M
-
Journal Title
Neuroreport
Volume: 23(2)
Pages: 113-8
-
[Journal Article] Long-term developmental outcome in patients with West syndrome after epilepsy surgery2012
Author(s)
Iwatani Y, Kagitani-Shimono K, Tominaga K, Okinaga T, Mohri I, Kishima H, Kato A, Sanefuji W, Yamamoto T, Tatsumi A, Murata E, Taniike M, Nagai T, Ozono K
-
Journal Title
Brain Dev
Volume: 34(9)
Pages: 731-8
-
-
-
-
-
[Presentation] Differential responses of mismatch field in autistm spectrum disorder with auditory hypersensitivity : a MEG study2013
Author(s)
Matsuzaki J, Kagitani-Shimono K, Sugata H, Hirata M, Hirata I, Hanaie R, Nagatani F, Tachibana M, Tominaga K, Mohri I, Taniike M
Organizer
Society for neuroscience
Place of Presentation
SanDiego (USA)
Year and Date
2013-11-15
-
[Presentation] Differential responses to aversive sound in autistic spectrum disorder with auditory hypersensitivity : A MEG study2013
Author(s)
Kagitani-Shimono K, Matsuzaki J, Sugata H, Hirata M, Hirata I, Hanaie R, Nagatani F, Tachibana M, Tominaga K, Mohri I, Taniike M
Organizer
ISACM
Place of Presentation
Sapporo
Year and Date
2013-08-28
-
-
-
-
