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2013 Fiscal Year Final Research Report

The creation of novel treatment and testing for developmental disorders based on the mechanisms of a developmental disorder model accompanying social abnormality.

Research Project

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Project/Area Number 23591501
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionGunma University

Principal Investigator

MITSUI Shinichi  群馬大学, 保健学研究科, 教授 (20295661)

Co-Investigator(Kenkyū-buntansha) GAMOH Keji  高知大学, 総合科学系, 教授 (90204817)
Co-Investigator(Renkei-kenkyūsha) YURI Kazunari  高知大学, 医歯学系, 教授 (10220534)
OSAKO Yoji  高知大学, 医歯学系, 准教授 (40335922)
Project Period (FY) 2011 – 2013
Keywords知的発達障害 / プロテアーゼ / 社会行動 / motopsin / neurotrypsin / sez-6
Research Abstract

The principal investigator has reported that the loss of motopsin, a serine protease in the brain, enhances social behaviors. In this research, we analyzed the effects of motopsin and sez-6, which was identified as a motopsin-binding protein, on the cell morphology when they were transfected in neuroblastoma cells. The results suggested that these proteinases coordinately modulate the morphology of neuronal cells. Further, we showed a possibility that serine proteases in the brain ordinarily modulate social behaviors, since the mice lacking tissue plasminogen activator, another protease in the brain, showed enhanced social anxiety in behavioral tests.

  • Research Products

    (14 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (10 results) (of which Invited: 1 results)

  • [Journal Article] The mental retardation related protease, motopsin (prss12), binds to the BRICHOS domain of the integral membrane protein 2a2014

    • Author(s)
      Mistui, S., Osako, Y., Yuri, K.
    • Journal Title

      Cell Biology International

      Volume: 38 Pages: 117-123

    • DOI

      10.1002/cbin.10164

    • Peer Reviewed
  • [Journal Article] A mental retardation gene, motopsin/prss12, modulates cell morphology by interaction with seizure related gene 62013

    • Author(s)
      Mitsui, S., Hidaka, C., Furihata, M., Osako, Y., Yuri, K.
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 436 Pages: 638-644

    • DOI

      10.1016/j.bbrc.2013.04.112

    • Peer Reviewed
  • [Journal Article] Dermokineβimpairs ERK signaling through direct binding to GRP782012

    • Author(s)
      Higashi, K., Hasegawa, M., Yokoyama, C., Tachibana, T., Mitsui, S., Saito, K.
    • Journal Title

      FEBS Letters

      Volume: 586 Pages: 2300-2305

    • DOI

      10.1016/j.febslet.2012.06.022

    • Peer Reviewed
  • [Journal Article] 唾液試料を用いた自閉症スペクトラム障害のメタボローム解析2011

    • Author(s)
      蒲生啓司,須貝一貴
    • Journal Title

      高知大学学術研究報告

      Volume: 60 Pages: 241-252

    • URL

      http://hdl.handle.net/10126/4848

  • [Presentation] Serine proteases modulating social behavior2013

    • Author(s)
      Mitsui, S.
    • Organizer
      Advanced Micro Device Engineering (AMDE2013)
    • Place of Presentation
      Kiryu, Japan
    • Year and Date
      2013-12-19
  • [Presentation] Function of seizure related gene 6 (sez 6)in neurite elongation and branching2013

    • Author(s)
      Hidaka, C., Mitsui, S.
    • Organizer
      Advanced Micro Device Engineering (AMDE2013)
    • Place of Presentation
      Kiryu, Japan
    • Year and Date
      2013-12-19
  • [Presentation] A serine protease in the brain modulates social behaviors2013

    • Author(s)
      Mitsui, S.
    • Organizer
      Brain and Health Informatics (BHI 2013)
    • Place of Presentation
      Maebashi, Japan
    • Year and Date
      2013-10-30
  • [Presentation] 唾液試料を用いる自閉症スペクトラム障害のメタボローム解析2013

    • Author(s)
      蒲生啓司,須貝一貴
    • Organizer
      第61回質量分析総合討論会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2013-09-10
  • [Presentation] Tissue type plasminogen activator modulates social anxiety2013

    • Author(s)
      Mitsui, S., Nakamura, K., Takabe,A., Shimizu, F., Okada, K., Matsuo, O.
    • Organizer
      日本神経科学学会(Neuro2014)
    • Place of Presentation
      京都
    • Year and Date
      2013-06-21
  • [Presentation] 脳内プロテオリシスの破綻による精神発達障害の発症機構2012

    • Author(s)
      三井真一
    • Organizer
      第59回北関東医学会総会
    • Place of Presentation
      前橋市
    • Year and Date
      2012-09-28
    • Invited
  • [Presentation] Metabolomic Analysis of Saliva of Autism Spectrum Disorders2012

    • Author(s)
      Gamoh, K., Sugai, K.
    • Organizer
      19th International Mass Spectrometry Conference
    • Place of Presentation
      Kyoto International Conference Centre, Kyoto
    • Year and Date
      2012-09-20
  • [Presentation] Modulation of neurite extension and branching by the interaction of a mental retardation gene, motopsin/neurotrypsin, and seizure related gene (sez)62011

    • Author(s)
      Hidaka, C., Mitsui, S., Yuri, K.
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-13
  • [Presentation] 精神遅滞原因遺伝子motopsin/neurotrypsinとSeizure related gene (Sez)6との相互作用によるニューロンの形態の制御2011

    • Author(s)
      三井真一,由利和也
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-09-16
  • [Presentation] 唾液試料を用いた自閉症のメタボロミクス研究(2)2011

    • Author(s)
      蒲生啓司,須貝一貴
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-16

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Published: 2015-07-16  

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