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2013 Fiscal Year Final Research Report

The pathophysiological and genetic analysis of Moyamoya disease using the patients-derived endothelial colony forming cells.

Research Project

  • PDF
Project/Area Number 23591502
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKyushu University

Principal Investigator

YOSHITO Ishizaki  九州大学, 大学病院, 助教 (20572944)

Co-Investigator(Kenkyū-buntansha) TORISU Hiroyuki  九州大学, 大学病院, 助教 (10398076)
Project Period (FY) 2011 – 2013
Keywordsもやもや病 / 細胞増殖
Research Abstract

We separated the endothelial colony forming cells from 6 patients with Moyamoya disease and control subjects. Then we analyzed the functions of RNF213 gene, that was reported as the first susseptibility gene of Moymoya disease. We found that RNF213 contributed to the pathogenesis of Moymoya disease in the process of inflammatory responses and the proliferation of endothelial cells and smooth muscle cells.

  • Research Products

    (3 results)

All 2012 Other

All Journal Article (1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] もやもや病感受性遺伝子RNF213の検討

    • Author(s)
      石崎義人,鳥巣浩幸,酒井康成,實藤雅文,山口結,原寿郎
    • Journal Title

      日本小児神経学会雑誌

      Volume: 44巻Suppl Pages: S279

  • [Presentation] もやもや病感受性遺伝子RNF213の検討2012

    • Author(s)
      石崎義人,鳥巣浩幸,酒井康成,實藤雅文,山口結,原寿郎
    • Organizer
      日本小児神経学会総会
    • Place of Presentation
      札幌
    • Year and Date
      20120500
  • [Remarks] 九州大学医学部小児科HP

    • URL

      http://www.med.kyushu-u.ac.jp/pediatr/

URL: 

Published: 2015-07-16  

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