2013 Fiscal Year Final Research Report
The pathophysiological and genetic analysis of Moyamoya disease using the patients-derived endothelial colony forming cells.
| Project/Area Number |
23591502
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TORISU Hiroyuki 九州大学, 大学病院, 助教 (10398076)
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| Project Period (FY) |
2011 – 2013
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| Keywords | もやもや病 / 細胞増殖 |
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| Research Abstract |
We separated the endothelial colony forming cells from 6 patients with Moyamoya disease and control subjects. Then we analyzed the functions of RNF213 gene, that was reported as the first susseptibility gene of Moymoya disease. We found that RNF213 contributed to the pathogenesis of Moymoya disease in the process of inflammatory responses and the proliferation of endothelial cells and smooth muscle cells.
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Research Products
(3 results)
