2013 Fiscal Year Final Research Report
Research of pathology-specific biomarkers for virus-related encephalopathy
| Project/Area Number |
23591503
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉良 龍太郎 (70304805)
實藤 雅文 (50467940)
石崎 義人 (20572944)
李 守永 (10529796)
酒井 康成 (10380396)
楠田 剛 (90710533)
礒部 菜摘 (50645992)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 急性脳症 |
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| Research Abstract |
The virus-related encephalopathy in childhood is mostly developed with non-specific CNS symptoms. Therefore it is clinically important to diagnose acute encephalopathy and to evaluate disease severity by laboratory findings. We carried out liquid chromatograph mass spectrometry using a cerebrospinal fluid specimen of patients with acute encephalopathy and controls. As a result, six specific fragments were detected. The signal level of the patients with acute encephalopathy was significantly higher than those of controls. The difference was clearer in the multivariate analysis. In addition, a detection power was the highest in a signal level of fragment 3, as a result of ROC analysis. But the association between signal level and clinical features such as a type or the pathogen was not clear.
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[Journal Article] Bilateral stenosis of carotid siphon in Hutchinson-Gilford progeria syndrome2013
Author(s)
Narazaki R, Makimura M, Sanefuji M, Fukamachi S, Akiyoshi H, So H, Yamamura K, Doisaki S, Kojima S, Ihara K, Hara T, Ohga S
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Journal Title
Brain Dev
Volume: 35
Pages: 690-3
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[Journal Article] Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus2013
Author(s)
Sakai Y, Ohkubo K, Matsushita Y, Akamine S, Ishizaki Y, Torisu H, Ihara K, Sanefuji M, Kim MS, Lee KU, Shaw CA, Lim J, Nakabeppu Y, Hara T
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Journal Title
Eur J Med Genet
Volume: 56
Pages: 475-83
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[Journal Article] Clinical and MRI characteristics of acute encephalopathy in congenital adrenal hyperplasia2011
Author(s)
Lee S, Sanefuji M, Watanabe K, Uematsu A, Torisu H, Baba H, Kira R, Takada Y, Ishizaki Y, Toyoshima M, Aragaki F, Hata D, Hara T
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Journal Title
J Neurol Sci
Volume: 306
Pages: 91-93
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