Role of calcium signaling on the endodermal stem cells in the metabolic syndrom from childhood.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591504
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kumamoto University
• Principal Investigator: NAKAMURA Kimitoshi 熊本大学, 医学部附属病院, 講師 (30336234)
• Project Period (FY): 2011 – 2013
• Keywords: メタボリック症候群 / 幹細胞 / 内胚葉 / カルシウム シグナル

Research Abstract

The metabolic syndrome is a high-risk group of arteriosclerotic diseases occurring such as obese, hyperlipidemia, hypertension and diabetes. It was elucidated that the onset of this metabolic syndrome was found in childhood recently. In this study, we established endodermal stem cells from calreticulin knockout mice and overexpression mice with tissue-specific calreticulin, and analyzed the function in the calcium signals. We elucidated a mechanism of the onset of the metabolic syndrome from the viewpoint of calcium signal which was important to the adjustment of the function of gene expression and the protein function.

Research Products

• [Journal Article] p.E66Q Mutation in the GLA Gene is Associated with a High Risk of Cerebral Small-Vessel Occlusion in Elderly Japanese Males (2014)
  • Author(s): Nakamura K, Sekijima Y, NakamuraK, Hattori K, Nagamatsu K, Shimizu Y, Yazaki M, Sakurai A, Endo F, Fukushima Y, Ikeda S
  • Journal Title: Eur J Neurol Volume: 21 Pages: 49-56
  • DOI: 10.1111/ene.12214
  • Peer Reviewed
• [Journal Article] Current status of hepatic glycogen storage disease in Japan : clinical manifestations(treatments and long-term outcomes. J. Hum.) (2013)
  • Author(s): Kido J, Nakamura K, Matsumoto S, Mitsubuchi H, Ohura T, Shigematsu Y, Yorifuji T, Kasahara M, Horikawa R and Endo F
  • Journal Title: Genet Volume: 58 Pages: 285-292
  • DOI: 10.1038/jhg.2013.17
  • Peer Reviewed
• [Journal Article] Nickel BE, Light PE, Dyck JRB, Lopaschuk GD, Kardami E, Opas M, and Michalak M Calreticulin induces dilated cardiomyopathy (2013)
  • Author(s): Lee D, Oka T, Hunter B, Robinson A, Papp S, Nakamura K, Srisakuldee W
  • Journal Title: Plos One Volume: 8 Pages: e56387
  • Peer Reviewed
• [Journal Article] VLCAD deficiency in a patient who recovered from VF, but died suddenly of an RSV infection (2013)
  • Author(s): Yamamoto A, Nakamura K, Matsumoto S, Iwai M, Shigematsu Y, Tajima G, Tsumura M, Okada S, Mitsubuchi H, Endo F
  • Journal Title: Pediatr Int Volume: 55 Pages: 775–778
  • Peer Reviewed
• [Journal Article] Newborn screening for Fabry disease in Japan : Prevalence and genotypes of Fabry disease in a pilot study (2013)
  • Author(s): Inoue T, Hattori K, Ihara K, Ishii A, Nakamura K, Hirose S
  • Journal Title: J. Hum. Genet Volume: 58 Pages: 548-552
  • DOI: 10.1038/jhg.2013.48
  • Peer Reviewed
• [Journal Article] Interactive network analysis of the plasma amino acids profile in a mouse model of hyperglycemia (2013)
  • Author(s): Tanaka T, Mochida T, Maki Y, Shiraki Y, Mori H, Matsumoto S, Shimbo K, Ando T, Nakamura K, Endo F, Okamoto M
  • Journal Title: Springerplus Volume: 2 Pages: 287
  • Peer Reviewed
• [Journal Article] Clinical features and management of organic acidemias in Japan. (J. Hum.) (2013)
  • Author(s): Fujisawa D, Nakamura K, Mitsubuchi H, Ohura T, Shigematsu Y, Yorifuji T, Kasahara M, Horikawa R and Endo F
  • Journal Title: Genet Volume: 58 Pages: 769-774
  • DOI: 10.1038/jhg.2013.97
  • Peer Reviewed
• [Presentation] Screening for Fabry Disease in Japan (2013)
  • Author(s): Kimitoshi Nakamura, MD
  • Organizer: 2013 Joint Meeting of the Newborn Screening and Genetic Testing Symposium and the International Society for Neonatal Screening
  • Place of Presentation: Atlanta Marriott Marquis(Atlanta, GA,USA)
  • Year and Date: 20130505-10
• [Presentation] Urea Cycle Disorders in Japan (2013)
  • Author(s): Kimitoshi Nakamura
  • Organizer: SHARE Meeting 2013
  • Place of Presentation: Mövenpick Hotel Amsterdam City Centre, Amsterdam, Netherlands
  • Year and Date: 2013-06-27
• [Presentation] Urea Cycle Amino Acids,Properties and Clinical Application. Role of Citrulline and Urea Cycle Disorders (2013)
  • Author(s): Kimitoshi Nakamura
  • Organizer: The 8th Asia Pacific Conference on Clinical Nutrition, 2013 The Tokyo Bay Maihama Hotel Club
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2013-06-10