2013 Fiscal Year Final Research Report
Analysis of boold-brain barrier breakdown in the early stage of acute encephalopathy
| Project/Area Number |
23591509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya City University |
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Principal Investigator |
ASAI Kiyofumi 名古屋市立大学, 医学(系)研究科(研究院), 教授 (70212462)
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| Co-Investigator(Kenkyū-buntansha) |
AOYAMA Mineyoshi 名古屋市立大学, 大学院医学研究科, 講師 (70363918)
KAKITA Hiroki 名古屋市立大学, 大学院医学研究科, 研究員 (40528949)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血液脳関門 / 急性脳症 / グリア細胞 / アストロサイト / ミクログリア / 血管内皮細胞 / サイトカイン |
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| Research Abstract |
To understand the pathophysiological mechanism of acute encephalopathy, and analyze the aggregative action of diclofenac sodium (DCF) on acute encephalopathy, we stimulated primary cultured rat astrocytes and microglia with IL-1beta;, TNF-alpha and IFN-gamma. The expression of iNOS and AQP4 and the production of NO were upregulated in astrocytes and the expression of iNOS and the activities of phagocytosis were increased in microglia. The addition of DCF highly enhanced the expression of iNOS and AQP4, and the activities of phagocytosis. This enhancement may explain the significantly increased mortality rates in acute encephalopathy patients treated with DCF.
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[Journal Article] Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury2011
Author(s)
Kato S, Aoyama M, Kakita H, Hida H, Kato I, Ito T, Goto T, Hussein MH, Sawamoto K, Togari H, Asai K.
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Journal Title
J Neurosci Res
Volume: 89(10)
Pages: 1566-74
DOI
Peer Reviewed
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