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2013 Fiscal Year Final Research Report

Immunomodulatory therapy of acute encephalopathy associated with hemolytic uremic syndrome

Research Project

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Project/Area Number 23591512
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionWakayama Medical University

Principal Investigator

MINAMI KOICHI  和歌山県立医科大学, 医学部, 講師 (60301438)

Co-Investigator(Kenkyū-buntansha) SUZUKI Hiroyuki  和歌山県立医科大学, 医学部, 准教授 (80196865)
YOSHIKAWA Norishige  和歌山県立医科大学, 医学部, 教授 (10158412)
Project Period (FY) 2011 – 2013
Keywords溶血性尿毒症症候群 / 急性脳症 / グリア細胞 / ケモカイン / Cannabinoids
Research Abstract

Infection with Shiga toxin (Stx)-producing Escherichia coli can lead to development of hemolytic uremic syndrome (HUS). Approximately 30% of patients with HUS suffer from central nervous system (CNS) complications and these patients have the poorest prognosis. It has been suggested that vascular endothelial injuries caused by Stxs play a crucial role in the development of the disease. Furthermore, the relationship of glial cell damage and Stxs is considered.
In this study, we investigated chemokine suppression mechanism using Cannabinoids in human astrocyte, and aimed to confirm the effect of disease specific therapy development based on the pathophysiology of HUS encephalopathy.

  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Book (3 results)

  • [Journal Article] 広範囲の白質裂傷を伴ったshaken baby syndromeの1乳児例2013

    • Author(s)
      南弘一,奥谷貴弘,津野嘉伸,杉本卓也,津田祐子,田村彰,柳川敏彦,吉川徳茂
    • Journal Title

      小児科臨床

      Volume: 66(7) Pages: 1601-1605

    • Peer Reviewed
  • [Journal Article] Chemokine expression in human astrocytes in response to shiga toxin 22012

    • Author(s)
      Kioka N, Minami K, Tamura A, Yoshikawa N.
    • Journal Title

      Int J Inflam. 2012

      Pages: 135803

    • Peer Reviewed
  • [Journal Article] Constructive Interference in Steady State (CISS)-MRI法が診断に有効であった前頭蓋底髄膜脳瘤の1例2011

    • Author(s)
      南弘一,五嶋文彦,中尾直之,大川都史香,田村彰,泉鉉吉,木岡直美,津田祐子,大松泰生,赤井美津代,吉川徳茂
    • Journal Title

      小児科臨床

      Volume: 64(8) Pages: 1887-1890

    • Peer Reviewed
  • [Book] 神経症候群(第2版)-その他の神経疾患を含めて-】感染性疾患細菌感染症サルモネラ日本臨床別冊神経症候群I2013

    • Author(s)
      南弘一
    • Total Pages
      795-798
  • [Book] 非チフス性サルモネラ菌,小児感染症マニュアル2012日本小児感染症学会編2012

    • Author(s)
      南弘一(東京)
    • Total Pages
      132-137
    • Publisher
      東京医学社
  • [Book] サルモネラ脳症,小児科臨床ピクシス28急性脳炎(急性脳症総編集五十嵐隆専門編集塩見正司)2011

    • Author(s)
      南弘一(東京)
    • Total Pages
      207-209
    • Publisher
      中山書店

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Published: 2015-07-16  

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