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2013 Fiscal Year Final Research Report

Analysis of pathogenesis of acute encephalopathy in children

Research Project

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Project/Area Number 23591518
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionJuntendo University

Principal Investigator

OKUMURA Akihisa  順天堂大学, 医学部, 准教授 (60303624)

Co-Investigator(Kenkyū-buntansha) HAYAKAWA Masahiro  名古屋大学, 医学部附属病院, 教授 (40343206)
HAYASHI Masaharu  財団法人東京都医学総合研究所, 脳発達神経再生研究分野, プロジェクトリーダー (00280777)
Project Period (FY) 2011 – 2013
Keywords自己免疫 / 抗神経抗体 / 急性脳症 / 免疫組織化学染色法 / 辺縁系脳炎 / 基底核脳炎
Research Abstract

Autoimmune process is presumed to contribute in acute encephalopathy in children. However, the methods for detecting autoantibodies have not been established. We measured serum autoantibodies in children with acute encephalopathy using several different methods. The subject of this study is 16 children with acute encephalopathy suspected to have autoimmune encephalopathy. We measured autoantibodies using the following methods: 1) immunoblot using prepared membrane with human brain derived proteins (IB), 2) immunohistochemical studies using rat brain tissue (rat IHC), 3) immunohistochemical studies using control human brain tissue (human IHC). Autoantibodies were detected in 5 children by IB, 11 by rat IHC, and 10 by human IHC. The results of examinations were not always consistent among methods of measurement. Our study revealed that IHC will be more sensitive than IB. However, the detection of autoantibody should be made in combination of several detection methods.

  • Research Products

    (33 results)

All 2013 2012 2011

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (15 results)

  • [Journal Article] Unexpected cardiopulmonary arrest associated with influenza : our experience during the 2009 pandemic in Japan2013

    • Author(s)
      Okumura A, et al.
    • Journal Title

      Influenza Other Respi Viruses

      Volume: 7 Pages: 759-760

    • Peer Reviewed
  • [Journal Article] Severe form of encephalopathy associated with 2009 pandemic influenza A (H1N1) in Japan2013

    • Author(s)
      Okumura A, et al.
    • Journal Title

      J Clin Virol

      Volume: 56 Pages: 25-30

    • Peer Reviewed
  • [Journal Article] Whole-exome sequencing of a unique brain malformation with periventricular heterotopia, cingulate polymicrogyria and midbrain tectal hyperplasia2013

    • Author(s)
      Okumura A, Hayashi M, et al.
    • Journal Title

      Neuropathology

      Volume: 33 Pages: 553-560

    • Peer Reviewed
  • [Journal Article] Acute limbic encephalitis with focal hyperperfusion on single photon emission computed tomography2013

    • Author(s)
      Igarashi A, Okumura A, Hayashi M, et al. (5名省略)
    • Journal Title

      Brain Dev

      Volume: 35 Pages: 181-184

    • Peer Reviewed
  • [Journal Article] Neonatal seizure identification on reduced channel EEG2013

    • Author(s)
      Kidokoro H, Kubota T, Hayakawa M, Kato Y, Okumura A.
    • Journal Title

      Arch Dis Child Fetal Neonatal Ed

      Volume: 98 Pages: F359-361

    • Peer Reviewed
  • [Journal Article] Safety evaluation of laninamivir octanoate hydrate through analysis of adverse events reported during early post-marketing phase vigilance2013

    • Author(s)
      Nakano T, Okumura A, et al. (6名省略)
    • Journal Title

      Scand J Infect Dis

      Volume: 45 Pages: 469-477

    • Peer Reviewed
  • [Journal Article] Acute encephalopathy in children with Dravet syndrome2012

    • Author(s)
      Okumura A, et al. (14名省略)
    • Journal Title

      Epilepsia

      Volume: 53 Pages: 79-86

    • Peer Reviewed
  • [Journal Article] Acute encephalopathy with 2009 pandemic flu : Comparison with seasonal flu2012

    • Author(s)
      Okumura A, et al. (8名省略)
    • Journal Title

      Brain Dev

      Volume: 34 Pages: 13-19

    • Peer Reviewed
  • [Journal Article] Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS)2012

    • Author(s)
      Miyata R, Hayashi M, Okumura A, et al. (8名省略)
    • Journal Title

      Brain Dev

      Volume: 34 Pages: 124-127

    • Peer Reviewed
  • [Journal Article] National survey of pandemic influenza A (H1N1) 2009-associated encephalopathy in Japanese children2012

    • Author(s)
      Kawashima H, Okumura A, et al. (3名省略、)
    • Journal Title

      J Med Virol

      Volume: 84 Pages: 1151-1156

    • Peer Reviewed
  • [Journal Article] Prognostic factors in acute encephalopathy with reduced subcortical diffusion2012

    • Author(s)
      Hayashi N, Okumura A, et al. (7名省略)
    • Journal Title

      Brain Dev

      Volume: 34 Pages: 632-639

    • Peer Reviewed
  • [Journal Article] Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children2012

    • Author(s)
      Kawashima H, Okumura A, et al. (3名省略)
    • Journal Title

      Scand J Infect Dis

      Volume: 44 Pages: 941-947

    • Peer Reviewed
  • [Journal Article] Deaths associated with pandemic (H1N1) 2009 among children, Japan, 2009–20102011

    • Author(s)
      Okumura A, et al. (11名省略)
    • Journal Title

      Emerg Infect Dis

      Volume: 17 Pages: 1993-2000

    • Peer Reviewed
  • [Journal Article] Acute encephalopathy in a child with secondary carnitine deficiency due to pivalate-conjugated antibiotics2011

    • Author(s)
      Okumura A, et al. (4名省略)
    • Journal Title

      Pediatr Infect Dis J

      Volume: 30 Pages: 92

    • Peer Reviewed
  • [Journal Article] Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures2011

    • Author(s)
      Okumura A, et al. (6名省略)
    • Journal Title

      Brain Dev

      Volume: 33 Pages: 77–82

    • Peer Reviewed
  • [Journal Article] Amplitude-integrated electroencephalography in preterm infants with cystic periventricular leukomalacia2011

    • Author(s)
      Kato T, Okumura A, Hayakawa M, et al. (3名省略)
    • Journal Title

      Early Hum Dev

      Volume: 87 Pages: 217-221

    • Peer Reviewed
  • [Journal Article] Chronological diffusion-weighted imaging changes and mutism in the course of rotavirus-associated acute cerebellitis/cerebellopathy concurrent with encephalitis/encephalopathy2011

    • Author(s)
      Kubota T, Okumura A, et al. (6名省略)
    • Journal Title

      Brain Dev

      Volume: 33 Pages: 21-27

    • Peer Reviewed
  • [Journal Article] Transient and mild reduction of consciousness during febrile illness in children2011

    • Author(s)
      Kato T, Okumura A, et al. (4名省略)
    • Journal Title

      Neuropediatrics

      Volume: 42 Pages: 183-187

    • Peer Reviewed
  • [Presentation] Attitude toward Epilepsy after Media Coverage of Car Accidents Related to Persons with Epilepsy in Japan2013

    • Author(s)
      Akihisa Okumura, et al
    • Organizer
      第47回日本てんかん学会学術集会
    • Place of Presentation
      北九州
    • Year and Date
      2013-10-11
  • [Presentation] 新生児発作に対するホスフェニトインの使用経験2013

    • Author(s)
      奥村彰久、他
    • Organizer
      第49回日本周産期・新生児医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-07-15
  • [Presentation] Attitude toward Epilepsy after Media Coverage of Car Accidents Related to Persons with Epilepsy in Japan2013

    • Author(s)
      Akihisa Okumura, et al
    • Organizer
      30th International Epilepsy Congress
    • Place of Presentation
      Montreal
    • Year and Date
      2013-06-24
  • [Presentation] Whole-exome sequencing identifies FLNB variant in a unique brain malformation2013

    • Author(s)
      Akihisa Okumura, et al
    • Organizer
      第55回小児神経学会総会
    • Place of Presentation
      大分
    • Year and Date
      2013-05-30
  • [Presentation] インフルエンザに伴う予期せぬ心肺停止:パンデミック2009小児死亡例の実態調査から2013

    • Author(s)
      奥村彰久、他
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2013-04-20
  • [Presentation] PRRT2 Mutation in Japanese Children with Benign Infantile Epilepsy2012

    • Author(s)
      Okumura, et al
    • Organizer
      The 16th Anunal Meeting of American Epilepsy Society
    • Place of Presentation
      San Diego
    • Year and Date
      2012-12-02
  • [Presentation] 新生児および乳幼児の発作-aEEGによる評価-2012

    • Author(s)
      奥村彰久
    • Organizer
      第46回日本てんかん学会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-10
  • [Presentation] Neonatal EEG in determining risk to the preterm brain2012

    • Author(s)
      Akihisa Okumura
    • Organizer
      Joint congress of the 12th International Child Neurology Congress and the 11th Asian and Oceanian Congress of Child Neurology
    • Place of Presentation
      Brisbane
    • Year and Date
      2012-06-01
  • [Presentation] Autoimmune encephalitis proven by immunohistochemical study2012

    • Author(s)
      Akihisa Okumura, et al
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-05-17
  • [Presentation] アトキンス食に伴う成長障害2012

    • Author(s)
      奥村彰久、他
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-19
  • [Presentation] 新生児発作・新生児発作様イベントの症状型分類の実証的検討2011

    • Author(s)
      奥村彰久、他
    • Organizer
      第56回日本未熟児新生児学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-14
  • [Presentation] 2番染色体長腕の微小重複を伴う難治性新生児てんかんの1例2011

    • Author(s)
      奥村彰久、他
    • Organizer
      第45回日本てんかん学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2011-10-06
  • [Presentation] Neonatal seizures and epilepsy2011

    • Author(s)
      Akihisa Okumura
    • Organizer
      29th International Epilepsy Congress
    • Place of Presentation
      Rome
    • Year and Date
      2011-09-01
  • [Presentation] 2009 Pandemic Flu A (H1N1)小児死亡例の実態調査2011

    • Author(s)
      奥村彰久、他
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-14
  • [Presentation] 2009 Pandemic Flu A (H1N1)による急性脳症死亡例の臨床像2011

    • Author(s)
      奥村彰久、他
    • Organizer
      第53回日本小児神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-05-27

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Published: 2015-07-16   Modified: 2016-01-05  

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