2013 Fiscal Year Final Research Report
Study on the epileptogenesis in child-onset intractable epilepsy
| Project/Area Number |
23591521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
HAYASHI Masaharu 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 参事研究員 (00280777)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 医療・福祉 / 臨床 / 脳・神経 / 病理学 / 生体試料 / 発達障害 / 難治てんかん / 脳症 |
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| Research Abstract |
In order to clarify the epileptogenesis in child-onset intractable epilepsy, we performed the immunohistochemical analysis in autopsy brains, and the examination of amino acids and neurotransmitter metabolites in the cerebrospinal fluid from patients, simultaneously. We succeeded in disclosing the abnormal expression of voltage-dependent sodium channels and/or the facilitation of autophagy in the cerebral cortex in cases of West syndrome, and the disturbed metabolism of amino acid and monoamines in patients with infantile convulsion.
In addition, we established the screening method of anti-neuronal antibodies in patients with subacute autoimmune encephalitis, which became to occur frequently in Japan, and explored the mechanisms of generation of refractory epilepsy in such encephalitis.
We believe that these data will give us a clue for developing new treatments in patients with refractory epilepsy.
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Research Products
(20 results)
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[Presentation] 形成異常2013
Author(s)
林雅晴
Organizer
第54回日本神経病理学会・第9回コアカリセミナー
Place of Presentation
東京
Year and Date
2013-04-24
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