Analysis and therapeutic research for growth impairment accompanied with chronic inflammatory syndrome of children as dysregulation of proinflammatory cytokines

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591546
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Yokohama City University
• Principal Investigator: YOKOTA Shumpei 横浜市立大学, 医学(系)研究科(研究院), 教授 (10158363)
• Co-Investigator(Renkei-kenkyūsha): IMAGAWA Tomoyuki 横浜市立大学, 附属病院, 准教授 (20336548) ; MIYAMAE Takako 横浜市立大学, 附属病院, 非常勤診療医 (90322354) ; KIKUCHI Masako 横浜市立大学, 附属病院, 助教 (90555129) ; NOZAWA Tomo 横浜市立大学, 附属病院, 指導診療医 (10588106)
• Project Period (FY): 2011 – 2013
• Keywords: 小児免疫学

Research Abstract

Growth impairment accompanied with systemic juvenile idiopathic arthritis (sJIA) is thought to be associated with suppression of proliferation of chondrocyte by IL-6, the key cytokine causing systemic inflammation, and suppression of bone extension by corticosteroid. Tocilizumab, anti-IL-6 receptor antibody, was approved in 2008 in Japan, so now bloadly used as treatment for steroid-refractory or -dependent sJIA. We have investigated height and height velocity of 45 sJIA patient administered with TCZ and analyzed correlation between them and several factors such as age, gender, disease duration and corticosteroid exposure, then inverse correlation between standard deviation score for height (HTSDS) and disease duration and strong correlation between reduction of corticosteroid and improvement of height velocity.

Research Products

• [Journal Article] Effect of Tocilizumab on growth impairment in systemic juvenile idiopathic arthritis with long-term corticosteroid therapy (2013)
  • Author(s): Miyamae T, Yokoya S, Yamanaka H, Yokota S.
  • Journal Title: Mod Rheumatol Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Radiologic analysis of the effect of tocilizumab on hands and large joints in children with systemic juvenile idiopathic arthritis (2013)
  • Author(s): Inaba Y, Ozawa R, Aoki C, Imagawa T, Mori M, Hara R, Miyamae T, Saito T, Yokota S.
  • Journal Title: Mod Rheumatol Volume: 23(4) Pages: 667-73
  • DOI: 10.1007/s10165-012-0711-0
  • Peer Reviewed
• [Journal Article] Efficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan (2012)
  • Author(s): Imagawa T, Takei S, Umebayashi H, Yamaguchi K, Itoh Y, Kawai T, Iwata N, Murata T, Okafuji I, Miyoshi M, Onoe Y, Kawano Y, Kinjo N, Mori M, Mozaffarian N, Kupper H, Santra S, Patel G, Kawai S, Yokota S.
  • Journal Title: Clin Rheumatol Volume: 31(12) Pages: 1713-21
  • DOI: 10.1007/s10067-012-2082-5
  • Peer Reviewed
• [Journal Article] Safety and efficacy of long-term etanercept in the treatment of methotrexate-refractory polyarticular-course juvenile idiopathic arthritis in Japan (2012)
  • Author(s): Mori M, Takei S, Imagawa T, Imanaka H, Nerome Y, Higuchi R, Kawano Y, Yokota S, Sugiyama N, Yuasa H, Fletcher T, Wajdula JS.
  • Journal Title: Mod Rheumatol Volume: 22(5) Pages: 720-6
  • DOI: 10.1007/s10165-011-0578-5
  • Peer Reviewed
• [Journal Article] Guidance on the use of adalimumab for juvenile idiopathic arthritis in Japan (2012)
  • Author(s): Yokota S, Imagawa T, Murata T, Tomiita M, Itoh Y, Fujikawa S, Takei S, Mori M.
  • Journal Title: Mod Rheumatol Volume: 22(4) Pages: 491-7
  • DOI: 10.1007/s10165-011-0561-1
  • Peer Reviewed
• [Journal Article] Definitive differences in laboratory and radiological characteristics between two subtypes of juvenile idiopathic arthritis : systemic arthritis and polyarthritis (2012)
  • Author(s): Ozawa R, Inaba Y, Mori M, Hara R, Kikuchi M, Higuchi R, Miyamae T, Imagawa T, Fujiwara T, Saito T, Yokota S.
  • Journal Title: Mod Rheumatol Volume: 22(4) Pages: 558-64
  • DOI: 10.1007/s10165-011-0540-6
  • Peer Reviewed
• [Presentation] Recent Advances in Pediatric Rheumatic Diseases from the Viewpoint of Dysregulation of Proinflammatory Cytokines (2013)
  • Author(s): Yokota S.
  • Organizer: APLAR Congress 2012
  • Place of Presentation: Amman Jordan
  • Year and Date: 2013-09-01
  • Invited