Genome instability caused by EVI1 oncogene activation

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591548
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Jichi Medical University
• Principal Investigator: KUME Akihiro 自治医科大学, 医学部, 准教授 (10264293)
• Co-Investigator(Renkei-kenkyūsha): ONODERA Masafumi (独)国立成育医療研究センター, 部長 (10334062)
• Project Period (FY): 2011 – 2013
• Keywords: 遺伝子 / ゲノム / エピジェネティクス / ヒストン修飾

Research Abstract

H3K9 methylation is considered to be one of crucial factors in tumor progression.

Research Products

• [Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells (2014)
  • Author(s): Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey T, Suzuki M, Ichimura K, Ozawa K.
  • Journal Title: Cancer Sci Volume: 105 Pages: 72-80
• [Journal Article] NF-B activity regulates mesenchymal stem cell accumulation at tumor sites (2013)
  • Author(s): Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K.
  • Journal Title: Cancer Res Volume: 73 Pages: 364-372
• [Journal Article] Suppression of lymph node and lung metastases of endometrial cancer by muscle-mediated expression of soluble VEGF receptor-3 (2013)
  • Author(s): Takahashi K, Mizukami H, Saga Y, Takei Y, Urabe M, Kume A, Machida S, Fujiwara H, Suzuki M, Ozawa K.
  • Journal Title: Cancer Sci Volume: 104 Pages: 1107-1111
• [Journal Article] CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models (2013)
  • Author(s): Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K.
  • Journal Title: Biochem Biophys Res Commun Volume: 438 Pages: 84-89
• [Journal Article] An R132H mutation in isocitrate dehydrogenase 1 enhances p21 expression and inhibits phosphorylation of retinoblastoma protein in glioma cells (2013)
  • Author(s): Miyata S, Urabe M, Gomi A, Nagai M, Yamaguchi T, Tsukahara T, Mizukami A, Kume A, Ozawa K, Watanabe E.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 53 Pages: 645-654
• [Journal Article] Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy (2012)
  • Author(s): Yagi H, Sanechika S, Ichinose H, Sumi-Ichinose C, Mizukami H, Urabe M, Ozawa K, Kume A.
  • Journal Title: NeuroReport Volume: 23 Pages: 30-34
• [Journal Article] Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats (2012)
  • Author(s): Ogura M, Urabe M, AkimotoT, Onishi A, Ito T, Tsukahara T, Mizukami H, Kume A, Muto S, Kusano E, Ozawa K.
  • Journal Title: Gene Ther Volume: 19 Pages: 476-482
• [Journal Article] Reciprocal upregulation of Notch signaling molecules in hematopoietic progenitor and mesenchymal stromal cells (2011)
  • Author(s): Kikuchi Y, Kume A, Urabe M, Mizukami H, Suzuki T, Ozaki K, Nagai T, Ozawa K.
  • Journal Title: J Stem Cells Regen Med Volume: 7 Pages: 61-68
• [Presentation] Accurate measurement of Nab status against AAV vector capsids and an approach toward managing its inhibitory effect (2013)
  • Author(s): Mizukami H, Mimuro J, Hishikawa S, Ikemoto T, Uchibori R, Tsukahara T, Urabe M, Kume A, Sakata A, Ohmori T, Madoiwa S, Sakata Y, Ozawa K.
  • Organizer: European Society of Gene and Cell Therapy and French Society for Cell and Gene Therapy Collaborative Congress 2013
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2013-10-25
• [Presentation] Tumor targeting using CD19-specific CAR (chimeric antigen receptor) for B-cell lymphoma (2013)
  • Author(s): Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K.
  • Organizer: American Society of Gene and Cell Therapy 16th Annual Meeting
  • Place of Presentation: Salt Lake City, UT, USA
  • Year and Date: 2013-05-18
• [Presentation] Precise evaluation of Nab status against adeno-associated viral vectors and an approach toward managing its inhibitory effect (2013)
  • Author(s): Mizukami H, Mimuro J, Hishikawa S, Ikemoto T, Uchibori R, Tsukahara T, Urabe M, Kume A, Sakata A, Ohmori T, Madoiwa S, Sakata Y, Ozawa K.
  • Organizer: American Society of Gene and Cell Therapy 16th Annual Meeting
  • Place of Presentation: Salt Lake City, UT, USA
  • Year and Date: 2013-05-16
• [Presentation] Evaluation of anti-tumor effevts mediated by engineered T lymphocytes expressing a CD19 specific CAR for B cell lymphoma (2012)
  • Author(s): Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
  • Organizer: American Society of Gene and Cell Therapy
  • Place of Presentation: Philadelphia, PA, USA
  • Year and Date: 2012-05-19
• [Presentation] Muscle-directed gene therapy for phenylketonuria with self-complementary AAV vectors (2011)
  • Author(s): Kume A, Yagi H, Mizukami H, Urabe M, Tsukahara T, Uchibori R, Ozawa K.
  • Organizer: XIXth Annual Congress of European Society of Gene and Cell Therapy
  • Place of Presentation: Brighton, UK
  • Year and Date: 2011-10-28
• [Presentation] Gene threrapy for phenylketonuria. Japan Society of Gene Therapy (2011)
  • Author(s): Kume A.
  • Organizer: 17th Annual Meeting
  • Place of Presentation: Fukuoka(Invited)
  • Year and Date: 2011-07-17