2013 Fiscal Year Final Research Report
Immunological analysis of the mechanism of oral immunotherapy for food allergy.
| Project/Area Number |
23591555
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fujita Health University |
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Principal Investigator |
TSUGE Ikuya 藤田保健衛生大学, 医学部, 教授 (00231431)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 経口免疫療法 / アレルゲン特異的T細胞 / 好塩基球活性化 |
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| Research Abstract |
We analyzed the mechanism of oral immunotherapy for food allergy immunologically, with the aim to establish a safe oral immunotherapy. In this study, we evaluated allergen-specific T cells and the activation of basophils in immunotherapy using hypo-allergic hydrolyzed milk. Milk allergen specific T cells were identified as CD154 positive cells after allergen stimulation, and intracytoplasmic cytokines were simultaneously analyzed by multi-color flow-cytometry (Galios). As a result, the milk allergic patients, compared to non-milk allergic patients, milk allergen-specific Th2 cytokine producing cells have increased significantly, and milk allergen-specific IL-4 producing cells were positively correlated with milk specific IgE. On the other hand, in the analysis of basophils, the reduction of Syk involved in signal from Fc epsilon RI was observed after immunotherapy, although the number of cases is still small. It is under investigation by increasing the number of cases currently.
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[Journal Article] Food sensitization in Japanese infants is associated with a common Filaggrin variant2013
Author(s)
Nomura T, Tsuge I, Inuo C, Nakajima Y, Kondo Y, Sugiura S, Murata H, Iguchi T,Terada A, Saitoh S, Hashimoto S, Urisu A.
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Journal Title
Ann Allergy Asthma Immunol
Volume: 110
Pages: 388-390
Peer Reviewed
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[Journal Article] Effect of Japanese cedar specific immunotherapy on allergen-specific T(H)2 cells in peripheral blood2013
Author(s)
Nomura T, Tsuge I, Inuo C, Nakajima Y, Tanaka K, Naruse N, Suzuki S, Ando H, Kondo Y, Saitoh S, Urisu A.
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Journal Title
Ann Allergy Asthma Immunol
Volume: 110
Pages: 380-385
Peer Reviewed
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[Journal Article] Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+) CD127(low)) cells in patients with immune dysregulation, poly endocrinopathy, enteropathy, X-linked syndrome2011
Author(s)
Otsubo K, Kanegane H, Kamachi Y, Kobayashi I, Tsuge I, Imaizumi M, Sasahara Y, Hayakawa A, Nozu K, Iijima K, Ito S, Horikawa R, Nagai Y, Takatsu K, Mori H, Ochs HD, Miyawaki T.
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Journal Title
Clin Immunol
Volume: 141
Pages: 111-20
Peer Reviewed
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[Presentation] 食物アレルギー最前線皮膚粘膜バリア機能と食物アレルギー2013
Author(s)
柘植郁哉,野村孝泰,近藤康人,中島陽一,森雄司,大久保悠里子,田中健一,山脇一夫,成瀬徳彦,犬尾千聡,平田典子,鈴木聖子,高松伸枝,宇理須厚雄
Organizer
第63回日本アレルギー学会秋季学術大会
Place of Presentation
東京
Year and Date
2013-11-28
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[Presentation] 食物アレルギーの経口免疫療法オボムコイド減量加熱全卵を用いた経口免疫療法の免疫学的検討2013
Author(s)
柘植郁哉,田中健一,野村孝泰,犬尾千聡,湯川牧子,高松伸枝,小倉和郎,成瀬徳彦,平田典子,鈴木聖子,安藤仁志,近藤康人,宇理須厚雄,山田一恵,小林幸子,木村守
Organizer
第61回日本アレルギー学会秋季学術大会
Place of Presentation
東京
Year and Date
2013-11-10
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[Presentation] オボムコイド減量加熱全卵を用いた経口免疫療法の免疫学的検討2011
Author(s)
柘植郁哉,田中健一,野村孝泰,犬尾千聡,湯川牧子,近藤康人,成瀬徳彦,平田典子,鈴木聖子,小倉和郎,小松原亮,安藤仁志,高松伸枝,山田一恵,小林幸子,木村守,宇理須厚雄
Organizer
第23回日本アレルギー学会春季臨床大会
Place of Presentation
東京
Year and Date
2011-05-14
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