2013 Fiscal Year Final Research Report
Analysis of the association between the abnormal skin and intestinal barrier function and food allergy.
| Project/Area Number |
23591556
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fujita Health University |
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Principal Investigator |
URISU Atsuo 藤田保健衛生大学, 医学部, 教授 (20193972)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 食物アレルギー / filaggrin / 皮膚バリア異常 |
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| Research Abstract |
For the purpose of verifying the relationship between food allergy and the skin barrier function, we examined the association of filaggrin (FLG) gene variation with clinical findings of food allergy in infants.
Subjects were 116 cases of infants (9 months to 14 months old) who were suspected food allergy and referred to Fujita Health University Ban Buntane Hotokukai hospital or its related facilities. FLG loss of function mutations, SNPs and copy number variations (CNVs) of FLG locus, were analyzed and their association with clinical findings, and laboratory findings were evaluated. As a result, association of a SNP present in the FLG gene promoter region with number of sensitized foods, and ImmnoCAP class of both egg and milk was observed. This SNP was considered to be in linkage disequilibrium with unknown loss-of-function mutations or promoter activity affecting its expression, and this finding is a new evidence suggesting the involvement of FLG on food sensitization.
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Research Products
(18 results)
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[Journal Article] Effect of Japanese cedar specific immunotherapy on allergen-specific TH2 cells in peripheral blood2013
Author(s)
Nomura T, Tsuge I, Inuo C, Nakajima Y, Tanaka K, Naruse N, Suzuki S, Ando H, Kondo Y, Saitoh S, Urisu A
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Journal Title
Ann Allergy Asthma Immunol
Volume: 110
Pages: 380-385
Peer Reviewed
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[Journal Article] Food sensitization in Japanese infants is associated with a common Filaggrin variant2013
Author(s)
Nomura T, Tsuge I, Inuo C, Nakajima Y, Kondo Y, Sugiura S, Murata H, Iguchi T, Terada A, Saitoh S, Hashimoto S, Urisu A
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Journal Title
Ann Allergy Asthma Immunol
Volume: 110
Pages: 388-390
Peer Reviewed
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[Journal Article] New approach for improving the safety of oral immunotherapy for food allergy2012
Author(s)
Urisu A, Tanaka K, Ogura K, Naruse N, Hirata N, Nakajima Y, Inuo C, Suzuki S, Ando H, Kondo Y, Tsuge I, Yamada K, Kimura, M.
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Journal Title
Clin Exp Allergy Rev
Volume: 12
Pages: 25–28
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[Journal Article] Effects of oral administration of Lactobacillus acidophilus L-92 on the symptoms and serum markers of atopic dermatitis in children2011
Author(s)
Torii S, Torii A, Itoh K, Urisu A, Terada A, Fujisawa T, Yamada K, Suzuki H,Ishida Y, Nakamura F, Kanzato H, Sawada D, Nonaka A, Hatanaka M, Fujiwara S.
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Journal Title
Int Arch Allergy Immunol
Volume: 154
Pages: 236
Peer Reviewed
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